Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice.

Acta Pharmacologica Sinica
Xin ZhangQi-Zhu Tang

Abstract

Pathological cardiac fibrosis is a common feature in multiple cardiovascular diseases that contributes to the occurrence of heart failure and life-threatening arrhythmias. Our previous study demonstrated that matrine could attenuate doxorubicin-induced oxidative stress and cardiomyocyte apoptosis. In this study, we investigated the effect of matrine on cardiac fibrosis. Mice received aortic banding (AB) operation or continuous injection of isoprenaline (ISO) to generate pathological cardiac fibrosis and then were exposed to matrine lavage (200 mg·kg-1·d-1) or an equal volume of vehicle as the control. We found that matrine lavage significantly attenuated AB or ISO-induced fibrotic remodeling and cardiac dysfunction. We also showed that matrine (200 μmol/L) significantly inhibited the proliferation, migration, collagen production, and phenotypic transdifferentiation of cardiac fibroblasts. Mechanistically, matrine suppressed p38 activation in vivo and in vitro, and overexpression of constitutively active p38 completely abolished the protective effects of matrine. We also demonstrated that ribosomal protein S5 (RPS5) upregulation was responsible for matrine-mediated inhibition on p38 and fibrogenesis. More importantly, matrine wa...Continue Reading

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Citations

Sep 15, 2020·Free Radical Research·Zhen-Zhong WuQi-Zhu Tang
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Wan-Li JiangSong-Ping Xie
May 2, 2021·Clinical and Translational Medicine·Zheng TangNitao Cheng
Jun 24, 2021·Immunopharmacology and Immunotoxicology·Weixin LiRuiyun Li
Jun 24, 2021·Free Radical Research·Zhe XiaoJia-Sheng Liu
Jul 13, 2021·Immunological Investigations·Cong WangMing Xu
Aug 10, 2021·Frontiers in Pharmacology·Sixuan ZhangJianlin Qiao
Sep 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ding-Yan LuTing Liu
Nov 17, 2021·Immunopharmacology and Immunotoxicology·Cong WangMing Xu

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