Matrine has pro-apoptotic effects on liver cancer by triggering mitochondrial fission and activating Mst1-JNK signalling pathways

The Journal of Physiological Sciences : JPS
Jian CaoShukun Yao

Abstract

Mitochondrial homeostasis is closely associated with liver cancer progression via multiple mechanisms and is also a potential tumour-suppressive target in clinical practice. However, the role of mitochondrial fission in liver cancer cell viability has not been adequately investigated. Matrine, a type of alkaloid isolated from Sophoraflavescens, has been widely used to treat various types of cancer. However, the molecular effect of matrine on mitochondrial homeostasis is unclear. Therefore, the aim of the current study was to determine the role of mitochondrial fission in cell apoptosis, viability, migration and proliferation of HepG2 cells in vitro. The effect of matrine on mitochondrial fission and its mechanism were also explored. The results of our study showed that HepG2 cells treated with matrine had reduced viability, an increased apoptotic rate, a blunted migratory response, and impaired proliferation capacity. At the molecular level, matrine treatment activated mitochondrial fission, which promoted mitochondrial dysfunction, caused cellular oxidative stress, disrupted cellular energy metabolism and initiated cell apoptotic pathways. However, blockade of mitochondrial fission abolished the deleterious effects of matrine ...Continue Reading

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Citations

Jun 2, 2020·Frontiers in Pharmacology·Hong ZhangCheng Guo
Oct 26, 2018·Canadian Journal of Gastroenterology & Hepatology·Xi-Zhen ChenYu-Sang Li
Oct 28, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Caiyan LiuHaiyang Yu
Jun 14, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shan WangShu-Yan Han

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Methods Mentioned

BETA
ELISA
fluorescence activated cell sorting
flow cytometry
transfection

Software Mentioned

ImageJ

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