Matrine induces mitochondrial apoptosis in cisplatin-resistant non-small cell lung cancer cells via suppression of β-catenin/survivin signaling

Oncology Reports
Huan-Qin WangJing Wang

Abstract

Matrine is an alkaloid isolated from Sophora flavescens and shows anticancer activities. The present study was carried out to determine the cytotoxic effects of matrine on cisplatin-resistant non-small cell lung cancer (NSCLC) cells and the associated molecular mechanisms. Parental and cisplatin-resistant A549 and H460 NSCLC cells were treated with 1 or 2 g/l of matrine for 48 h, and cell viability and apoptosis were assessed. β-catenin-mediated transcriptional activity, mitochondrial membrane potential (ΔΨm) changes, activation of caspases, and survivin expression were examined. The effect of overexpression of survivin on the anticancer activity of matrine was investigated. Compared to the parental cells, cisplatin-resistant NSCLC cells showed increased β-catenin transcriptional activity. Matrine treatment resulted in a significant reduction in β-catenin activation and survivin expression in the cisplatin-resistant cells. Matrine caused apoptotic death in the cisplatin-resistant NSCLC cells, coupled with loss of ΔΨm and activation of caspase-9 and -3. Matrine-induced apoptosis of the cisplatin-resistant NSCLC cells was significantly reversed by overexpression of survivin. In conclusion, matrine exposure induces mitochondrial a...Continue Reading

References

Oct 6, 1997·The Journal of Biological Chemistry·K OrfordS W Byers
Nov 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Rafael RosellNoemi Reguart
Mar 5, 2003·Journal of Cell Science·Bradley W Doble, James R Woodgett
Jun 3, 2004·Nature Reviews. Drug Discovery·Philip Cohen, Michel Goedert
Aug 3, 2004·Science·Douglas R Green, Guido Kroemer
Feb 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giannicola D'AddarioFrances A Shepherd
Nov 24, 2006·Molecular Cancer Therapeutics·Hadas Dvory-SobolNadir Arber
Jun 7, 2007·Journal of the National Cancer Institute·Andrea ArdizzoniUNKNOWN CISCA (CISplatin versus CArboplatin) Meta-analysis Group
Sep 26, 2008·The New England Journal of Medicine·Roy S HerbstScott M Lippman
Jan 16, 2010·Biochemical and Biophysical Research Communications·Ying TengDaoxin Ma
Sep 6, 2011·Oncogene·L GalluzziG Kroemer
Aug 31, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yajun YangJiangning Liu
Jun 13, 2013·Molecular and Cellular Biochemistry·Yongpeng WeiJunhua Lu
Jun 21, 2013·International Journal of Cancer. Journal International Du Cancer·Kaijie HeAmir Goldkorn
Nov 10, 2013·OncoTargets and Therapy·Chun Hei Antonio CheungJang-Yang Chang
Feb 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan LiuChangqing Su
Apr 11, 2014·Molecular Medicine Reports·Bu-Shan XieShu-Kun Yao

❮ Previous
Next ❯

Citations

Apr 22, 2017·Chemical Communications : Chem Comm·Dongyao WangYifeng Chai
Oct 17, 2015·Blood Cancer Journal·B C ValdezB S Andersson
Feb 6, 2018·Experimental and Therapeutic Medicine·Jianguang JiaJun Qian
Jun 2, 2020·Frontiers in Pharmacology·Hong ZhangCheng Guo
Aug 27, 2019·The Journal of Clinical Investigation·Chaoyun PanSumin Kang
Oct 26, 2016·Molecular Medicine Reports·Chao NieLei Zhang
Oct 26, 2018·European Journal of Medicinal Chemistry·Haroon Ur RashidJun Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis