Matrine Mediates Inflammatory Response via Gut Microbiota in TNBS-Induced Murine Colitis

Frontiers in Physiology
Peiyuan LiJing Yang

Abstract

This study mainly investigated the effect of matrine on TNBS-induced intestinal inflammation in mice. TNBS treatment caused colonic injury and gut inflammation. Matrine (1, 5, and 10 mg/kg) treatment alleviated colonic injury and gut inflammation via reducing bleeding and diarrhea and downregulating cytokines expression (IL-1β and TNF-α). Meanwhile, serum immunoglobulin G (IgG) was markedly reduced in TNBS treated mice, while 5 and 10 mg/kg matrine alleviated IgG reduction. Fecal microbiota was tested using 16S sequencing and the results showed that TNBS caused gut microbiota dysbiosis, while matrine treatment markedly improved gut microbiota communities (i.e., Bacilli and Mollicutes). Functional analysis showed that cell motility, nucleotide metabolism, and replication and repair were markedly altered in the TNBS group, while matrine treatment significantly affected cell growth and death, membrane transport, nucleotide metabolism, and replication and repair. In conclusion, matrine may serve as a protective mechanism in TNBS-induced colonic inflammation and the beneficial effect may be associated with gut microbiota.

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Citations

Dec 17, 2019·Current Pharmaceutical Design·Fan CaoHai-Feng Pan
Apr 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Sicong LiLei Bi
Oct 7, 2020·Journal of Receptor and Signal Transduction Research·Qiubei LuBinhao Wang
Oct 13, 2020·Frontiers in Pharmacology·Longtai YouJian Ni

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Methods Mentioned

BETA
PCR

Software Mentioned

PICRUSt
SPSS
Primer

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