Matriptase activation, an early cellular response to acidosis.

The Journal of Biological Chemistry
I-Chu TsengChen-Yong Lin

Abstract

Extracellular acidosis often rapidly causes intracellular acidification, alters ion channel activities, and activates G protein-coupled receptors. In this report, we demonstrated a novel cellular response to acidosis: induction of the zymogen activation of matriptase. Acid-induced matriptase activation is ubiquitous among epithelial and carcinoma cells and is characterized by rapid onset, fast kinetics, and the magnitude of activation seen. Trace amounts of activated matriptase can be detected 1 min after cells are exposed to pH 6.0 buffer, and the vast majority of latent matriptase within the cells is converted to activated matriptase within 20 min. Matriptase activation may be a direct response to proton exposure because acid-induced matriptase activation also occurs in an in vitro, cell-free setting in which intracellular signaling molecules and ion channel activities are largely absent. Acid-induced matriptase activation takes place both on the cell surface and inside the cells, likely due to the parallel intracellular acidification that activates intracellular matriptase. Following matriptase activation, the active enzyme is immediately inhibited by binding to hepatocyte growth factor activator inhibitor 1, resulting in st...Continue Reading

References

May 1, 1984·The American Journal of Physiology·K IchiharaY Abiko
Apr 4, 1997·The Journal of Biological Chemistry·L W KlompJ D Gitlin
Aug 13, 1998·Alimentary Pharmacology & Therapeutics·A G PressG Ramadori
Sep 20, 2000·The Journal of Biological Chemistry·C Z WangS Seino
Sep 20, 2001·The Journal of Membrane Biology·M Soleimani, C E Burnham
Jan 17, 2002·The Journal of Biological Chemistry·Christelle BenaudChen-Yong Lin
Dec 25, 2002·Clinical & Experimental Metastasis·Christelle M BenaudChen-Yong Lin
May 10, 2003·The Journal of Biological Chemistry·Michael D OberstChen-Yong Lin
Jul 2, 2003·European Journal of Medicinal Chemistry·B MasereelD Laeckmann
Jul 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michael D OberstChen-Yong Lin
Jul 26, 2003·The Journal of Investigative Dermatology·Jean-Pierre HachemPeter M Elias
Sep 5, 2003·Nature·Marie-Gabrielle LudwigKlaus Seuwen
Oct 1, 1962·The Journal of Clinical Investigation·I CHERNEW, A I BRAUDE
Nov 26, 2003·The Journal of Cell Biology·Karin ListThomas H Bugge
Jul 29, 2004·The Journal of Biological Chemistry·Naoka MurakamiTakao Shimizu
Nov 30, 2004·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Robert J GilliesRobert A Gatenby
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Michael D OberstChen-Yong Lin
May 5, 2005·Applied and Environmental Microbiology·Ryan C Hunter, Terry J Beveridge
May 19, 2006·Cancer Research·Robert A GatenbyRobert J Gillies
Jul 21, 2006·The Journal of Physical Chemistry. B·Nathalie Marcotte, Albert M Brouwer
Aug 19, 2006·The Journal of Physiology·Caroline J TaylorStephen B Hladky
Mar 9, 2007·American Journal of Physiology. Cell Physiology·Ming-Shyue LeeChen-Yong Lin
Sep 21, 2007·Journal of Cell Science·Jonathan R MathiasAnna Huttenlocher

❮ Previous
Next ❯

Citations

Oct 5, 2011·Journal of Medicinal Chemistry·Zhenghong XuChen-Yong Lin
Jul 9, 2011·Journal of Biochemistry·Kenji Kojima, Kuniyo Inouye
Jul 29, 2011·American Journal of Physiology. Cell Physiology·Feng-Pai ChouChen-Yong Lin
Oct 28, 2011·American Journal of Physiology. Cell Physiology·Han XuChen-Yong Lin
Dec 3, 2010·American Journal of Physiology. Cell Physiology·Cheng-Jueng ChenChen-Yong Lin
Apr 20, 2012·PloS One·Arkadiusz WelmanMargaret C Frame
Feb 28, 2013·The Journal of Biological Chemistry·Baoyu ZhaoJacky Chi Ki Ngo
Feb 22, 2012·Cell and Tissue Research·Gregory S Miller, Karin List
Nov 15, 2011·The Journal of Investigative Dermatology. Symposium Proceedings·Ulf Meyer-Hoffert, Jens-Michael Schröder
Aug 1, 2013·The Journal of Investigative Dermatology·Ya-Wen ChenChen-Yong Lin
Sep 28, 2013·The American Journal of Pathology·Feng-Pai ChouChen-Yong Lin
Sep 6, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Bai-Yao WuChen-Yong Lin
Feb 20, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Yi-Lin ChiuChen-Yong Lin
Jul 15, 2015·American Journal of Physiology. Cell Physiology·Abdo J NajyHyeong-Reh C Kim
Sep 19, 2019·Cancer Metastasis Reviews·Carly E Martin, Karin List
Jun 15, 2018·Oncotarget·Gulam M RatherJoseph R Bertino
Oct 30, 2018·Journal of Cellular and Molecular Medicine·Fang YeHu Zhou
Nov 10, 2018·The Journal of Biological Chemistry·Trine TambergJan K Jensen
Apr 27, 2019·Frontiers in Oncology·Gulam M RatherJoseph R Bertino
Jun 3, 2021·International Journal of Molecular Sciences·Emma L CarrollS Lorraine Martin

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.