Matrix composition in opossum esophagus

Digestive Diseases and Sciences
K SchulzeJ Martin

Abstract

The esophagus of mammalian species is organized into mucosa, connective tissue, and muscle, but little is known about the matrix of these layers. We studied by immunohistochemistry the distribution of collagens, fibronectin, versican, and elastin in the smooth muscle segment of the American opossum. Cryosections were exposed to specific antibodies and fluorescent-stained using conjugates of rhodamine or isothiocyanate. Staining was scored by two observers. We found that collagen I was prominent in the submucosa and in the muscular septa; collagen III formed fibrillar meshes in the lamina propria and the submucosa but was virtually absent from the epithelial and muscular layers; collagen IV was restricted to the base of the epithelium; collagen V, in contrast to collagen III, was prominent in epithelium and muscularis mucosae and sparse in muscular septa and submucosa. Fibronectin distribution followed collagen III; it formed layers in lamina propria and submucosa and strands in muscle septa and between individual muscle cells. Versican distribution followed collagen V; it was prominent in large muscle septa and formed thick sheets at the boundaries of submucosa/circular muscle and of circular/longitudinal muscle. We also determ...Continue Reading

Citations

Jul 13, 2012·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Eleni A StavropoulouDimitrios P Sokolis
Sep 15, 2011·Biotechnology and Bioengineering·J Y TanL P Tan
Jan 7, 2014·Expert Review of Medical Devices·Guillaume LucLaurence Bordenave
Apr 11, 2019·Polymers·Hidemi Hattori, Masayuki Ishihara
Mar 22, 2006·Tissue Engineering·Amit D BhranyBuddy D Ratner

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