Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Cell
Kandice R LeventalValerie M Weaver

Abstract

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis is accompanied by collagen crosslinking, ECM stiffening, and increased focal adhesions. Induction of collagen crosslinking stiffened the ECM, promoted focal adhesions, enhanced PI3 kinase (PI3K) activity, and induced the invasion of an oncogene-initiated epithelium. Inhibition of integrin signaling repressed the invasion of a premalignant epithelium into a stiffened, crosslinked ECM and forced integrin clustering promoted focal adhesions, enhanced PI3K signaling, and induced the invasion of a premalignant epithelium. Consistently, reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence. These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy.

References

Jun 5, 1999·Journal of Biomedical Materials Research·T S GirtonR T Tranquillo
Jun 27, 2000·Biophysical Journal·C M LoY L Wang
Jun 28, 2000·Physics in Medicine and Biology·R SinkusD Holz
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
Apr 11, 2002·Nature Cell Biology·Cindy K Miranti, Joan S Brugge
Feb 11, 2003·Journal of Cellular Biochemistry·Herbert M Kagan, Wande Li
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Charlotte KuperwasserRobert A Weinberg
Jun 16, 2005·Biochimica Et Biophysica Acta·Annemarie J van der SlotAnne-Marie Zuurmond
Aug 9, 2005·Pathologie-biologie·Kornelia Molnarne SzauterKatalin Csiszar
Aug 13, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Brent J PfeifferCharlotte L Phillips
Sep 20, 2005·Cancer Cell·Matthew J PaszekValerie M Weaver
Apr 28, 2006·Nature·Janine T ErlerAmato J Giaccia
Jun 24, 2006·Nature Reviews. Cancer·Brian Bierie, Harold L Moses
Jul 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Muhammad H ZamanPaul Matsudaira
Aug 16, 2006·Cellular and Molecular Life Sciences : CMLS·H A Lucero, H M Kagan
Aug 22, 2006·Current Opinion in Cell Biology·Satyajit K Mitra, David D Schlaepfer
Nov 3, 2006·Cancer Research·Janine T Erler, Amato J Giaccia
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Andrea Page-McCawZena Werb
May 2, 2007·Journal of Cellular Biochemistry·Stacey L PayneDawn A Kirschmann
Jul 24, 2007·Nature Cell Biology·Menachem KatzYosef Yarden
Aug 10, 2007·Journal of Cellular Biochemistry·Lynne-Marie PostovitDawn A Kirschmann
Oct 13, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Penelope C GeorgesRebecca G Wells
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hicham LahlouWilliam J Muller
Dec 19, 2007·The Journal of Cell Biology·Pierre-Jean WipffBoris Hinz
May 6, 2008·Cancer Cell·Min HuKornelia Polyak
Sep 25, 2008·Clinical & Experimental Metastasis·Janine T Erler, Valerie M Weaver
Jan 24, 2009·Nature Reviews. Cancer·Darci T ButcherValerie M Weaver

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Citations

Jan 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Carmen Chak-Lui WongGregg L Semenza
Jun 22, 2011·Cell and Tissue Research·Michael K WendtWilliam P Schiemann
Apr 23, 2011·Journal of Neural Transmission·Chris J Weston, David H Adams
Dec 14, 2011·Biomechanics and Modeling in Mechanobiology·Cecillia LuiCeleste M Nelson
Jan 22, 2011·Annals of Biomedical Engineering·Adrian C Shieh
Apr 6, 2013·Biomedical Microdevices·Peter DelNeroClaudia Fischbach
Aug 3, 2012·Breast Cancer Research and Treatment·Andreas Pettersson, Rulla M Tamimi
Apr 14, 2010·Cancer Metastasis Reviews·Claudia ChiodoniSabina Sangaletti
Nov 22, 2011·Cancer Metastasis Reviews·Paolo Cirri, Paola Chiarugi
Apr 25, 2012·Cancer Metastasis Reviews·Katharine L SodekMaurice J Ringuette
Jun 16, 2012·Cancer Metastasis Reviews·Jonathan P Sleeman
Jun 12, 2012·Clinical & Experimental Metastasis·Jenny A Rudnick, Charlotte Kuperwasser
Jan 19, 2013·Clinical & Experimental Metastasis·Shawn P CareyCynthia A Reinhart-King
Sep 3, 2010·Journal of Mammary Gland Biology and Neoplasia·Ori MallerPepper Schedin
Mar 31, 2011·Journal of Mammary Gland Biology and Neoplasia·Jenny G ParvaniWilliam P Schiemann
Jul 27, 2011·Journal of Mammary Gland Biology and Neoplasia·Tim Kees, Mikala Egeblad
Jan 8, 2011·Pharmaceutical Research·Hillary Holback, Yoon Yeo
Jun 1, 2011·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Wan-Yin ZhaiYuan-Sen Xu
Jul 13, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Nikolce GjorevskiCeleste M Nelson
Apr 25, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Qian Xiao, Gaoxiang Ge
May 26, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Jie LiZhihai Qin
Feb 23, 2013·The International Journal of Biochemistry & Cell Biology·Jiangling XiongErik H J Danen
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Thordur Oskarsson
Feb 5, 2013·Cancer Letters·Maria Letizia TaddeiPaola Chiarugi
Mar 12, 2013·Cancer Letters·Chevaun D MorrisonWilliam P Schiemann
May 11, 2013·Differentiation; Research in Biological Diversity·Qike K ChenCeleste M Nelson
Oct 12, 2013·Experimental Cell Research·Seiichiro IshiharaHisashi Haga
Jun 7, 2013·Biomacromolecules·William G HerrickShelly R Peyton
Oct 12, 2013·Cell Death & Disease·C WielD Bernard
Jun 13, 2012·Cell Research·Mario Andres BlancoYibin Kang
Jun 4, 2013·Nature Cell Biology·Ori MallerValerie M Weaver

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