Matrix effects in the analysis of polar organic water contaminants with HILIC-ESI-MS.

Analytical and Bioanalytical Chemistry
Kathrin MüllerThomas P Knepper

Abstract

Matrix effects have been shown to be very pronounced and highly variable in the analysis of mobile chemicals, which may severely exacerbate accurate quantification. These matrix effects, however, are still scarcely studied in combination with hydrophilic interaction liquid chromatography (HILIC) and for very polar chemicals. In this study, the matrix effects of 26 polar model analytes were investigated in enriched drinking water, wastewater treatment plant effluent and solutions of inorganic salts, utilizing post-column infusion of the analytes into a HILIC-electrospray ionisation (ESI)-high-resolution mass spectrometry system. These experiments revealed the occurrence of structure-specific and unspecific matrix effects. The unspecific matrix effects were mainly observed in positive ESI polarity and predominantly coincided with a high ion count, resulting in ion suppression of all analytes. Thus, the excess charge is hypothesized to be the limiting factor in ion formation. Structure-specific matrix effects were more pronounced in negative ESI polarity and even structurally similar compounds were observed to react entirely differently: perfluoroalkyl carboxylic acids were suppressed, while perfluoroalkane sulfonic acids were sim...Continue Reading

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Mar 27, 2018·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Alfred HaglindCurt E Pettersson

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Citations

Feb 23, 2020·Analytical and Bioanalytical Chemistry·Daniel ZahnThomas P Knepper
Jun 8, 2021·Analytical Chemistry·Selina TislerJan H Christensen

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