Matrix metallopeptidase 9 as a host protein target of chloroquine and melatonin for immunoregulation in COVID-19: A network-based meta-analysis

Life Sciences
Suvojit HazraNilkanta Chakrabarti

Abstract

The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. The differentially expressed genes (DEGs) were identified from microarray data repository of SARS-CoV patient blood. The repurposed drugs for COVID-19 were selected from available literature. Using DEGs and drugs, the protein-protein interaction (PPI) and chemo-protein interaction (CPI) networks were constructed and combined to develop an interactome model of PPI-CPI network. The top-ranked sub-network with its hub-bottleneck nodes were evaluated with their functional annotations. A total of 120 DEGs and 65 drugs were identified. The PPI-CPI network (118 nodes and 293 edges) exhibited a top-ranked sub-network (35 nodes and 174 connectivities) with 12 hub-bottleneck nodes having two drugs chloroquine and melatonin in association with 10 proteins corresponding to six upregulated and four downregulated genes. Two drugs interacted directly with the hub-bottleneck node i.e. matrix metallopeptidase 9 (MMP9), a host protein correspon...Continue Reading

Citations

Dec 4, 2020·Nanomedicine·Virna Margarita Martín GiménezRussel J Reiter
Jun 3, 2021·Briefings in Bioinformatics·Zulkar NainSudhangshu Kumar Biswas
Jun 22, 2021·Frontiers in Immunology·Jon Hazeldine, Janet M Lord
Jul 3, 2021·Chemical Society Reviews·Eugene N MuratovAlexander Tropsha
Aug 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Carolina D Avila-MesquitaChristiane Becari

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Methods Mentioned

BETA
bronchoalveolar
lavage

Software Mentioned

Enrichr
STRING
Cytoscape
limma
VIBGYOR
Bioconductor
R
ELANE
CentiScaPe
STITCH

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