Matrix Metalloproteases as Influencers of the Cells' Social Media

International Journal of Molecular Sciences
Daniel YoungAntoine Dufour

Abstract

Matrix metalloproteinases (MMPs) have been studied in the context of cancer due to their ability to increase cell invasion, and were initially thought to facilitate metastasis solely through the degradation of the extracellular matrix (ECM). MMPs have also been investigated in the context of their ECM remodeling activity in several acute and chronic inflammatory diseases. However, after several MMP inhibitors failed in phase III clinical trials, a global reassessment of their biological functions was undertaken, which has revealed multiple unanticipated functions including the processing of chemokines, cytokines, and cell surface receptors. Despite what their name suggests, the matrix aspect of MMPs could contribute to a lesser part of their physiological functions in inflammatory diseases, as originally anticipated. Here, we present examples of MMP substrates implicated in cell signaling, independent of their ECM functions, and discuss the impact for the use of MMP inhibitors.

References

Dec 1, 1995·The Journal of Experimental Medicine·N KayagakiH Yagita
Jun 21, 1996·The Journal of Biological Chemistry·A ItoY Mori
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·E LeviI Vlodavsky
Nov 12, 1996·Biochemical and Biophysical Research Communications·S ChandlerG Wells
Jan 1, 1997·Advances in Cancer Research·D NaorD Ish-Shalom
Feb 12, 1998·The Journal of Biological Chemistry·S OrlandoA Mantovani
Apr 8, 1998·Annual Review of Neuroscience·J G Flanagan, P Vanderhaeghen
Oct 31, 1998·Current Opinion in Immunology·S ShrestaT J Ley
May 31, 2001·The Journal of Cell Biology·M KajitaM Seiki
Dec 14, 2001·The Journal of Biological Chemistry·Boris I RatnikovAlex Y Strongin
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shoji UeharaPaul E Love
Jul 24, 2002·FEBS Letters·Augustin AmourGillian Murphy
Mar 26, 2003·Cell Death and Differentiation·H WajantP Scheurich
May 24, 2003·Brain : a Journal of Neurology·Inge NelissenGhislain Opdenakker
Sep 16, 2003·Nature Cell Biology·Daniel J MarstonCatherine D Nobes
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric M TamChristopher M Overall
Sep 15, 2004·Biochemistry·Alexey M BelkinAlex Y Strongin
May 17, 2005·Cancer Cell·Conor C LynchMitsuru Futakuchi
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert D BerahovichThomas J Schall
May 24, 2005·Biochimica Et Biophysica Acta·Marcus E PeterBryan C Barnhart
Mar 29, 2006·Journal of Biochemistry·Munirah AhmadHiroshi Sato

❮ Previous
Next ❯

Citations

Feb 13, 2020·Journal of Clinical Medicine·Nuria Garcia-FernandezMaría José Soler
Feb 7, 2020·Journal of Developmental Biology·Christopher D SmallBryan D Crawford
May 10, 2020·Biomolecules·Helena LaronhaJorge Caldeira
May 3, 2020·Cells·Helena Laronha, Jorge Caldeira
Apr 25, 2020·International Journal of Molecular Sciences·Alice LuddiPaola Piomboni
Apr 16, 2020·International Journal of Molecular Sciences·Magnus S Ågren, Ulrich Auf dem Keller
Jan 3, 2020·Clinical & Experimental Metastasis·Geetanjali P Rai, Sarah K Baird
Dec 8, 2020·Oxidative Medicine and Cellular Longevity·Patricia LlorenteMaria J Bullido
Jan 6, 2021·Pharmaceuticals·Nabangshu DasAntoine Dufour
Jan 7, 2021·Japanese Journal of Ophthalmology·Keitaro MashimoNobuyuki Ebihara
Apr 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Masataka UmedaGeorge C Tsokos
Jun 10, 2021·Antiviral Research·Patricia LlorenteMaria J Bullido
Aug 8, 2021·International Journal of Molecular Sciences·Anna Hrabia
Aug 8, 2021·International Journal of Molecular Sciences·Marina MarozziFederica Rizzi
Sep 8, 2021·Journal of Proteome Research·Longxiang WangAntoine Dufour

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
xenograft

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Sameeksha ChopraAntoine Dufour
Histology and Histopathology
N Johansson, Veli-Matti Kähäri
Frontiers in Bioscience : a Journal and Virtual Library
Barbara Fingleton
© 2021 Meta ULC. All rights reserved