Matrix metalloproteases as molecular markers in gastric cancer

Medicina clínica
Sol de la PeñaKenneth León-Córdoba

Abstract

Gastric cancer is the second leading cause of cancer-associated mortality in the world. Prognosis in patients with gastric cancer is difficult to establish because it is commonly diagnosed when gastric wall invasion and metastasis have occurred. Currently, some members of the extracellular matrix metalloproteinases have been identified, whose expression in gastric tumor tissue is significantly elevated compared to healthy gastric tissue. Matrix metalloproteinases are 24 zinc-dependent endopeptidases that catalyze the proteolysis of the extracellular matrix. This degradation allows the cancer cells invade the surrounding stroma and trigger metastasis. Upregulation of certain matrix metalloproteinases in gastric cancer has been associated with a poor prognosis and elevated invasive capacity. This review compiles evidence about the genetic expression of matrix metalloproteinases in gastric cancer and their role in tumour invasion and metastasis, emphasizing their potential as molecular markers of prognosis.

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Citations

Sep 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Cynthia Farias Vieira de MeloEleonidas Moura Lima
Jan 26, 2016·Enfermería intensiva·M Acevedo-NuevoB E Martin-Rivera
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Feb 26, 2016·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Anatoly P BurlakaEvgeny P Sidorik

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