Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits.

The American Journal of Pathology
Sohsuke YamadaYasuyuki Sasaguri

Abstract

Whether fatty streaks are directly followed by fibrous plaque formation in atherosclerosis remains controversial. Disruption of the basement membrane and elastic layers is thought to be essential for this process. Matrix metalloproteinase 12 (MMP-12) can degrade a broad spectrum of substrates, but the role of MMP-12 in the early stage of atherosclerosis is unclear. To investigate MMP-12 function in the initiation and progression of atherosclerosis, we investigated macrophage migration and elastolysis in relation to fatty streaks in human MMP-12 transgenic (hMMP-12 Tg) rabbits. Fatty streaks in hMMP-12 Tg rabbits fed a 1% cholesterol diet for 6 weeks (cholesterol-induced model of atherosclerosis) were more pronounced and were associated with more significant degradation of the internal elastic layer compared with wild-type (WT) animals. Numbers of infiltrating macrophages and smooth muscle cells in the lesions were increased in hMMP-12 Tg compared with WT animals. In both cuff- and ligation-induced models of atherosclerosis, smooth muscle cell-predominant atherosclerotic lesions were elevated with significant elastolysis of the internal elastic lamina in Tg compared with WT animals; "microelastolytic sites" were recognized befor...Continue Reading

References

Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·Y SasaguriM Morimatsu
Oct 1, 1980·The Journal of Clinical Investigation·R M SeniorR P Mecham
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·A HorvaiC K Glass
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z S GalisP Libby
Aug 1, 1994·Laboratory Investigation; a Journal of Technical Methods and Pathology·Y SasaguriM Morimatsu
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J M ShipleyS D Shapiro
Nov 1, 1996·The Biochemical Journal·J R MacBeathC A Shuttleworth
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Mar 18, 2000·Biochemical and Biophysical Research Communications·L WuT Watanabe
Mar 8, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Lihua WuTeruo Watanabe
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Apr 16, 2005·Circulation Research·Yasuyuki SasaguriHiroshi Ohtsu
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason L JohnsonChristopher L Jackson
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tong SunDongxin Lin

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Citations

Jan 29, 2011·Current Atherosclerosis Reports·Daniel F J Ketelhuth, Magnus Bäck
Aug 18, 2010·Antioxidants & Redox Signaling·Amir RezvanHanjoong Jo
May 3, 2012·Antioxidants & Redox Signaling·Xin GuoYasuyuki Sasaguri
Sep 9, 2009·Rheumatology·Alicia Rodríguez-PlaMark J Soloski
Sep 11, 2009·Current Opinion in Lipidology·Jason L Johnson, Andrew C Newby
Jan 8, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jason L JohnsonVincent Dive
Nov 22, 2011·Molecular Aspects of Medicine·Diego SbardellaMassimo Coletta
Mar 17, 2010·Progress in Cardiovascular Diseases·Magnus BäckStefan Agewall
Mar 31, 2009·Pulmonary Pharmacology & Therapeutics·Nancy GarbackiAlain Colige
Nov 27, 2015·Scientific Reports·Shu-Lin LiuRichard K Assoian
Jul 1, 2014·Basic & Clinical Pharmacology & Toxicology·Aline AzevedoRaquel F Gerlach
Jun 21, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kevin Tak-Pan NgKwan Man
May 24, 2016·Progress in Biophysics and Molecular Biology·Z BőszeA Varró
Jun 25, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Rachel D SimmonsHanjoong Jo
Oct 4, 2016·Annals of Medicine·Flavia Del PortoMaurizio Taurino
May 9, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Isabel GoncalvesUNKNOWN SUMMIT Consortium
Apr 30, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Sohsuke YamadaYasuyuki Sasaguri
Jan 4, 2020·European Heart Journal·Stevan D StojanovićDaniel G Sedding
Feb 6, 2017·Molecular Neurobiology·Bharath ChelluboinaKrishna Kumar Veeravalli
Feb 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satish K MadalaThomas A Wynn

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