Matrix metalloproteinase-2 may be involved with increased bone loss associated with experimental periodontitis and smoking: a study in rats

Journal of Periodontology
João Batista César NetoF H Nociti

Abstract

Smoking has been associated with periodontitis severity and is considered a risk factor for its development. It has been reported that matrix metalloproteinase (MMP) produced by host cells plays a major role in periodontal tissue destruction. Thus, the present study tested, in rats, the hypothesis that local increased levels of MMP-2 would be associated with the enhanced periodontitis-related bone loss after intermittent cigarette smoke inhalation (CSI). Twenty-seven adult male Wistar rats were used. A ligature was placed around one of the mandibular first molars of each animal and they were randomly assigned to the following control (N = 13) or CSI (N = 14) group. Sixty days later, the animals were sacrificed, the gingival tissues harvested, and the specimens processed for decalcified sections. Extracts from the gingival tissues were prepared and assayed for MMP-2 expression. Intergroup comparisons (unligated sites) showed that CSI might directly affect alveolar bone (0.16 +/- 0.03 mm2 versus 0.24 +/- 0.09 mm2 for non-smokers and smokers, respectively; P = 0.001). Moreover, CSI significantly enhanced bone loss resulting from experimental periodontitis (0.64 +/- 0.36 mm2 versus 1.50 +/- 0.50 mm2 for non-smokers and smokers, res...Continue Reading

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Citations

Feb 4, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Isabel M PortoRaquel F Gerlach
Mar 6, 2007·Journal of Periodontology·Alvaro Francisco BoscoValdir Gouveia Garcia
Apr 3, 2007·Journal of Periodontology·Getúlio da R Nogueira-FilhoUrbino da R Tunes
Nov 10, 2012·Journal of Periodontology·Juliane Almeida AbdoSuzana Peres Pimentel
Jul 14, 2011·Lasers in Medical Science·Valdir Gouveia GarciaLetícia Helena Theodoro
Sep 1, 2005·Journal of Clinical Periodontology·Giovanni E Salvi, Niklaus P Lang
Feb 28, 2006·Journal of Periodontal Research·João Batista César-NetoFrancisco Humberto Nociti
Jan 18, 2008·Journal of Clinical Periodontology·Dana T GravesGeorge Hajishengallis
Dec 17, 2014·Periodontology 2000·Francisco H NocitiPoliana Mendes Duarte
Apr 8, 2011·Archives of Oral Biology·Julie Teresa MarchesanYvonne L Kapila
Oct 25, 2016·Archives of Oral Biology·J I AguirreD B Kimmel
Jan 18, 2013·Brazilian Oral Research·João Batista César NetoGiuseppe Alexandre Romito
Jan 17, 2009·Brazilian Oral Research·Fernando Renó de LimaGetulio Rocha Nogueira-Filho
Nov 1, 2018·Brazilian Oral Research·Rahşan Atasoy ŞentürkBinnaz Handan Özdemir
Oct 23, 2020·Archives of Oral Biology·Marcelo Queiroz D'ÂngeloRodrigo Villamarim Soares

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