Matrix metalloproteinase-2: Not (just) a "hero" of the past

Biochimie
Patrick Henriet, Hervé Emonard

Abstract

The 72-kDa type IV collagenase or gelatinase A is the second member of the matrix metalloproteinase family, MMP-2. Since the discovery of its first two substrates within components of the extracellular matrix, denatured interstitial type I collagen and native type IV collagen, the roles and various levels of regulation of MMP-2 have been intensively studied, mainly in vitro. Its (over)expression in most if not all tumors was considered a hallmark of cancer aggressiveness and boosted investigations aiming at its inhibition. Unfortunately, the enthusiasm subsided like a soufflé after clinical trial failures, mostly because of insufficient knowledge of in vivo MMP-2 activities and detrimental side effects of broad-spectrum MMP inhibition. Nowadays, MMP-2 remains a major topic of interest in research, the second in the MMP family after MMP-9. This review presents a broad overview of the major features of this protease. This knowledge is crucial to identify diagnostic or therapeutic strategies focusing on MMP-2. In this sense, recent publications and clinical trials underline the potential value of measuring circulating or tissular MMP-2 levels as diagnostic or prognostic tools, or as a useful secondary outcome for therapies against...Continue Reading

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Citations

Jan 16, 2020·International Journal of Molecular Sciences·Olivera EvrovaJohanna Buschmann
Jan 12, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Antonio CelentanoNicola Cirillo
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marta BaczewskaPaweł Knapp
Jun 8, 2021·Frontiers in Medicine·Ceylan OnursalClaudia A Staab-Weijnitz
Jun 15, 2021·Frontiers in Cardiovascular Medicine·Jiefang ChenLing Mao

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