Matrix metalloproteinase-2 promoter genotype as a marker of cutaneous T-cell lymphoma early stage.

Journal of Biomedicine & Biotechnology
Anna VaskůVladimir Vasku

Abstract

The aim of the study was to investigate the DNA polymorphic genotype in MMP-2 promoter gene as a potential candidate region for the development of the cutaneous T-cell lymphoma (CTCL) and/or its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls of similar age and sex distribution, without personal or family history of chronic skin diseases and without personal history of malignancy. The three selected polymorphisms in the promoter of MMP-2 gene (-1575G/A, -1306C/T, and -790T/G) were determined using the PCR-based methodology with RFLP. In our cohort, the associated GGCCTT MMP-2 promoter genotype was highly significantly more frequent in CTCL-Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.). To conclude, use of associated MMP-2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.

References

Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A VaccaF Dammacco
Oct 19, 2001·Journal of the American Academy of Dermatology·M Kashani-SabetH S Zackheim
Mar 3, 2004·The Journal of Pathology·Kazuki NabeshimaMasahiro Kikuchi
Mar 5, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Anna VaskůJirí Vácha
May 4, 2005·Cancer Research·Achim KrügerRafael Fridman
May 23, 2006·Oncogene·E DeniaudY Leverrier
Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sonja HahtolaAnnamari Ranki
Mar 7, 2007·Acta Dermato-venereologica·Claire BernierBrigitte Dreno
May 15, 2009·Indian Journal of Dermatology, Venereology and Leprology·K N Sarveswari, Patrick Yesudian
Nov 11, 2009·Molecular and Cellular Biology·Paul M EvansChunming Liu

❮ Previous
Next ❯

Citations

Jan 20, 2015·Journal of Cellular and Molecular Medicine·Katarzyna KamińskaAnna M Czarnecka
Jul 1, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·V SlonkováV Vašků
Aug 8, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rania M BakrySalma Mahfouz
Apr 10, 2020·Archives of Dermatological Research·Berenika OlszewskaMałgorzata Sokołowska-Wojdyło
Jul 21, 2012·The American Journal of Dermatopathology·Marier Hernández-Pérez, Meera Mahalingam

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Transfac Matrix
MatInspector

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.