PMID: 25735351Mar 5, 2015Paper

Matrix metalloproteinase-9 -1562T allele and its combination with MMP-2 -735 C allele are risk factors for breast cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Zohreh RahimiZiba Rahimi

Abstract

Expression of matrix metalloproteinases (MMPs) is up-regulated in human cancers. The aim of present study was to investigate the role of MMP-9 C-1562T polymorphism and its interaction with MMP- 2 C-735T polymorphism in susceptibility to breast cancer in a population from Western Iran with Kurdish ethnic background. The study sample of 205 individuals consisted of 101 breast cancer patients and 104 healthy subjects. MMP-9 C-1562T and MMP-2 C-735T variants were identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Among 67.4% of studied patients the breast cancer developed in the third and forth decades of the life. The frequency of MMP-9 T allele was 17.3% in patients and 10.1% in controls. The presence of T allele significantly increased the risk of breast cancer by 1.87-fold [OR=1.87 (95% CI 1.05-3.33, p=0.035)]. The frequency of MMP-9 CT+TT genotype tended to be higher in those patients with a family history of cancer in first degree-relatives (36.8%) than those without a family history (28.3%, p=0.37). We observed an interaction between the MMP-9 -1562 T allele with MMP-2 -735 C allele that significantly increased the risk of breast cancer [OR=1.42 (95% CI 1.02- 1.98, p=0....Continue Reading

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Citations

Dec 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kheirollah YariZohreh Rahimi
May 27, 2020·Molecular and Clinical Oncology·Fawziya Abd Elmaogoud Ragab IbrahimNadia Ahmed Abd El Moneim
Mar 29, 2020·Royal Society Open Science·Rafael Camacho-MejoradoAbraham Majluf-Cruz
May 13, 2020·Breast Cancer Research and Treatment·Suélène Georgina DofaraCaroline Diorio

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