Matrix metalloproteinase-9,-3 and tissue inhibitor of matrix metalloproteinase-1 in colorectal cancer: relationship to clinicopathological variables

Cell Biochemistry and Function
Hüray IşlekelAli Küpelioğlu

Abstract

The balance between matrix metalloproteinases (MMPs) and their physiological tissue inhibitors of matrix metalloproteinases (TIMPs) is crucial in tumour invasion and progression. The aim of this study was to investigate the levels of MMP-9, MMP-3 and TIMP-1 in colorectal cancer (CRC) and to evaluate these proteinases and their inhibitor with respect to clinicopathological variables. Activities of pro- and active MMP-9 were measured in paired tumour and distant normal tissue specimens from 43 patients with CRC using gelatin zymography. ELISA was employed for the determination of MMP-9, MMP-3 and TIMP-1 protein expressions. The activity levels of pro- and active MMP-9 and protein expression levels of MMP-9, MMP-3 and TIMP-1 were higher in tumour tissues than in the corresponding normal tissues; the differences being significant for all (p < 0.05), except TIMP-1. Similarly, active MMP-9/proMMP-9 and the ratio of protein expression level of MMP-9-TIMP-1 were found to be significantly higher in tumour tissues ( p < 0.01). Among all the clinicopathological variables investigated, significant correlations were found between MMP-9 and presence of perineural invasion, MMP-3 and lymph node status, TIMP-1 and tumour differentiation, MMP-9...Continue Reading

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Citations

Mar 19, 2008·Pathology Oncology Research : POR·László HerszényiZsolt Tulassay
Nov 6, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Z CavdarG Oktay
Jan 28, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pallavi GargShanthi V Sitaraman
Mar 10, 2007·BMC Medical Genetics·Javier CotignolaIrene Orlow
Feb 19, 2010·Folia Histochemica Et Cytobiologica·Barbara MroczkoMaciej Szmitkowski
Aug 31, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Søren Astrup JensenJens Benn Sørensen
Jun 23, 2012·Digestive Diseases·Gábor LakatosLászló Herszényi
Mar 14, 2013·Bulletin of Experimental Biology and Medicine·N E KushlinskiiV V Prorokov
Dec 2, 2008·Bulletin of Experimental Biology and Medicine·E S GershteinN E Kushlinsky
Jan 8, 2011·The Tohoku Journal of Experimental Medicine·Saulius SvagzdysDainius Pavalkis
Sep 29, 2020·Frontiers in Endocrinology·Veronica VeschiMatilde Todaro

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