Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in diagnosis of pleural effusion of malignant origin

Interactive Cardiovascular and Thoracic Surgery
Alfonso FiorelliAngelina DI Carlo

Abstract

The aim of the present study was to evaluate the diagnostic accuracy of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in differentiating benign from malignant exudative pleural effusions. This is a unicentre observational study including 97 consecutive patients with exudative pleural effusions. Metalloproteinase-9, tissue inhibitor of metalloproteinase-1, lactate dehydrogenase, ferritin, carcinoembryonic antigen and carbohydrate antigen 15-3 were measured in pleural effusion and serum by enzyme-linked immunosorbent assay. The activity of metalloproteinase-9 was also evaluated by substrate zymography. The data were correlated with final diagnosis of pleural effusions to evaluate the diagnostic accuracy. Of the 97 eligible patients, 6 were excluded. Of the 91 patients included in the study, 70 had malignant pleural effusions and 21 had benign pleural effusions. Both in sera and pleural effusions, matrix metalloproteinase-9 (P < 0.0001), tissue inhibitor of metalloproteinase-1 (P < 0.0001) and carcinoembryonic antigen (P < 0.0001) levels were higher in neoplastic patients than in benign group. Zymography analysis showed a most prominent band at a molecular weight of 92 kDa (metalloproteinase-9) whereas a l...Continue Reading

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Citations

Jun 11, 2019·Journal of Cellular Physiology·Mariarosaria BoccellinoMarina Di Domenico
Dec 7, 2018·Journal of Cellular Physiology·Marina Di DomenicoGiulio Caracciolo
Aug 29, 2019·Frontiers in Endocrinology·Marina Di DomenicoMariarosaria Boccellino
Aug 4, 2020·Asian Cardiovascular & Thoracic Annals·Amr M AllamaIslam M Ibrahim

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