Matrix metalloproteinase-9 contributes to the increase of tau protein in serum during acute ischemic stroke

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Jacek KurzepaHalina Bartosik-Psujek

Abstract

Previous studies indicate that tau protein, a marker of damage to neurons, is present in the serum of healthy patients at a concentration approximately 40 percent that of patients with ischemic stroke We assumed that increased serum activity of gelatinases (matrix metalloproteinase [MMP]-2 and MMP-9) can influence the level of tau protein in serum, probably due to disruption of the blood-brain barrier. We obtained blood sera from 31 patients admitted within the first 24 hours of ischemic stroke on days 1, 5 and 10, following the onset of stroke. Tau protein was detected in the serum of 12 patients (38.7 percent). The highest MMP-9 activity was recorded on day 5 (p < 0.05). Serum gelatinase activity did not differ between tau protein-positive or -negative individuals. However, a high degree of correlation between mean MMP-9 activity and the maximum tau protein level was observed for patients with detectable tau protein (r = 0.71, p = 0.009). Our study suggests that MMP-9 can increase the tau protein level in the sera of patients during acute ischemic stroke.

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Citations

Nov 30, 2010·Journal of Angiogenesis Research·Eugen B PetcuMaria M Opris
Jan 19, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Sarah E BuerkiUNKNOWN Swiss Neuropediatric Stroke Registry Study Group
Aug 4, 2012·The Annals of Thoracic Surgery·Michael SecoMichael P Vallely
Dec 7, 2013·The International Journal of Neuroscience·Jacek KurzepaJoanna Bielewicz
Jun 19, 2012·Clinical Biochemistry·Hai-Tao HuLiang Zhang
Dec 17, 2019·Aging·Xin Chen, Hua Jiang
Jun 17, 2020·Journal of Alzheimer's Disease : JAD·Mario Hernandes-AlejandroJosé Luna-Muñoz
May 6, 2020·International Journal of Molecular Sciences·Ryszard PlutaStanisław J Czuczwar
Mar 9, 2021·Frontiers in Aging Neuroscience·Ryszard PlutaStanisław J Czuczwar

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