Matrix metalloproteinase-9 gene polymorphisms and their interaction with environment on subarachnoid hemorrhage risk

Experimental Biology and Medicine
Tao WangJing Wang

Abstract

The current study aimed to investigate the relations of three single nucleotide polymorphisms of matrix metalloproteinase-9 gene, and single nucleotide polymorphisms-smoking interaction to subarachnoid hemorrhage risk. The optimal pattern of the interaction among single nucleotide polymorphisms and smoking was selected by generalized multifactor dimensionality reduction. The association between the three single nucleotide polymorphisms within the matrix metalloproteinase-9 gene was analyzed by logistic regression test. As well as genetic risk of subarachnoid hemorrhage interactions with smoking, the risk of subarachnoid hemorrhage in carriers with the rs3918242 (T) was significantly higher than in carriers carrying CC (genotype: CT + TT vs. CC), adjusted OR (95% CI) = 1.58 (1.25-2.03), and in carriers carrying rs17576- (genotype: AG + GG vs. AA), adjust OR (95% CI) = 1.62 (1.19-2.13). However, after adjusting for covariates, we did not find any direct association between rs17577 and subarachnoid hemorrhage risk. The generalized multifactor dimensionality reduction model shows a potential relation between rs3918242 and smoking risk for subarachnoid hemorrhage ( P = 0.0010). After covariates adjustment, current smokers with rs391...Continue Reading

References

Sep 1, 1995·Journal of Neurosurgery·W I SchievinkD G Piepgras
Apr 1, 1996·Stroke; a Journal of Cerebral Circulation·F H LinnJ van Gijn
Jun 1, 2005·Free Radical Biology & Medicine·K Jian Liu, Gary A Rosenberg
Nov 12, 2005·Stroke; a Journal of Cerebral Circulation·Valery L FeiginCraig S Anderson
Jan 13, 2006·Cardiovascular Research·Hideaki NagaseGillian Murphy
Feb 21, 2009·Stroke; a Journal of Cerebral Circulation·Marie Søfteland SandveiAnne Vik

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SPSS

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