Matrix Metalloproteinase-9 (MMP-9) Gene Polymorphism in Stroke Patients

Neuromolecular Medicine
Kinga BuraczynskaKonrad Rejdak

Abstract

Matrix metalloproteinases (MMPs), endopeptidases degrading extracellular matrix, play an important role in the pathogenesis of atherosclerosis and vascular disease. The aim of this study was to evaluate the association between the C(-1562)T functional polymorphism in the MMP-9 gene and risk of stroke. We examined 322 patients with stroke and 410 controls. In the patient group, 52 % had type 2 diabetes. All subjects were genotyped for the C(-1562)T polymorphism by polymerase chain reaction and restriction analysis. A significant increase in T allele and CT + TT genotype frequencies was observed in patients compared with controls (OR 1.73, 95 % CI 1.34-2.23 and 1.89, 95 % CI 1.39-2.56, respectively). The T allele carriers were younger at the onset of stroke (63.5 ± 11.7 years) than patients with CC genotype (71 ± 14.1 years) (p = 0.0002). The comparison between patients with T2DM and without it showed that the T allele and CT + TT genotype were more frequent in T2DM patients (OR 1.48, 95 % CI 1.03-2.12 for T allele and 1.44, 95 % CI 1.93-2.24 for CT + TT genotype). In conclusion, our findings suggest that MMP-9 C(-1562)T polymorphism is significantly associated with risk of stroke in patients with and without T2DM.

References

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Citations

Aug 17, 2016·International Journal of Molecular Sciences·Jason J ChangTayebeh Pourmotabbed
Oct 30, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xiao-Ya HuangZu-Sen Ye
Aug 23, 2018·Journal of Cellular Biochemistry·Baohua WangLei Zhao
Dec 31, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·I S SeverinaA E Medvedev
Dec 14, 2016·Disease Markers·Jacek KurzepaMassimiliano Castellazzi
Mar 29, 2020·Royal Society Open Science·Rafael Camacho-MejoradoAbraham Majluf-Cruz
Aug 28, 2021·International Journal of Molecular Sciences·Sebastian AndoneRodica Balasa

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SPSS

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