Matrix metalloproteinase activities and oxidative stress in newborn cardiac tissue of rabbit female fed high cholesterol-methionine diet

Archives of Physiology and Biochemistry
Sarah Ait-BenaliYasmina Benazzoug

Abstract

We study the effect of an enriched cholesterol-methionine diet administered to females on the cardiac tissue remodelling of the offspring during two successive pregnancies. Two groups are constituted, standard diet (SD) group fed a standard diet and CD group fed a combined diet (standard + cholesterol 1%-methionine 0.25%). The diet is administered during 80 days. The results show changes in serum and cardiac parameters of CD newborn, with the involvement of phospholipids (PLs) (phosphatidylethanolamine (PE) and phosphatidylcholine (PC), variations in malondialdehyde (MDA), conjugated diene (CD), and vitamin C [VIT-C] rates). Under the CD effect, serum matrix metalloproteinase (MMP)-2, pro-MMP-9, and MMP-9 activities change. As to cardiac MMP-2 activity, a rise is noticed in the second pregnancy. Histological analysis reveals constricted blood capillaries, collagen fibre deposits, and lipid accumulation in the CD newborn heart. Our study shows the amplified effect of the maternal cholesterol-methionine diet in the second pregnancy on newborn cardiac disorders (matrix remodelling, oxidative stress, and lipid accumulation).

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jan 1, 1983·Cardiovascular Research·I Medugorac, R Jacob
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G N PierceN S Dhalla
Jan 1, 1984·Methods in Enzymology·H Aebi
Nov 15, 1982·Analytical Biochemistry·S K Jagota, H M Dani
May 1, 1996·Kidney International·V Witko-SarsatB Descamps-Latscha
May 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T A Goddijn-WesselT K Eskes
Jul 9, 1999·Progress in Lipid Research·F M Goñi, A Alonso
May 1, 2001·Journal of Clinical Pathology·D KoracevicV Cosic
Jan 7, 2003·The Journal of Nutrition·Silvana M L Turbino-RibeiroMaria Lucia Pedrosa
Jul 17, 2003·Endocrinology·Christina ChristoffersenLars B Nielsen
Jun 25, 2004·Biology of Reproduction·Tom P FlemingJudith J Eckert
Aug 17, 2004·The Biochemical Journal·Alfredo MartínezFrank Cuttitta
Sep 27, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher A Maloney, William D Rees
Dec 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Marina R BergmanDavid H Lovett
Dec 30, 2006·Biochemical and Biophysical Research Communications·Suko AdiartoMitsuhiro Yokoyama
Jun 27, 2007·British Journal of Pharmacology·A K ChowR Schulz
Aug 28, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sanjoy GhoshSheila M Innis
Sep 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·M C PustovrhE González
Oct 23, 2008·Metabolism: Clinical and Experimental·Verónica MiksztowiczGabriela Berg
Aug 6, 2009·Journal of Cardiovascular Translational Research·Wulf PalinskiClaudio Napoli
Aug 7, 2009·Cardiovascular Research·Arulmozhi D KandasamyRichard Schulz
Jul 6, 2010·The International Journal of Biochemistry & Cell Biology·Kaïs H Al-GuboryCatherine Garrel
Mar 15, 2011·Pflügers Archiv : European journal of physiology·Thomas K Borg, Troy A Baudino
Jan 31, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Michael R ZileFrancis G Spinale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.