PMID: 9171509Dec 1, 1996Paper

Matrix metalloproteinases-1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection

Oral Diseases
L MellanenT Sorsa

Abstract

Human immunodeficiency virus (HIV)-seropositive patients have frequently severe gingival inflammation and/or attachment loss. In addition many infectious diseases affect their periodontium with varying clinical manifestations. Matrix metalloproteinases seem to play a key role in physiological periodontal remodelling and pathological tissue destruction. The aim of the present study was to characterize the presence, molecular forms, cellular sources, activities, and relative amounts of fibroblast-type (matrix metalloproteinase [MMP]-1) and neutrophil (MMP-8) collagenases, as well as their potential activator stromelysin-I (MMP-3) and myeloperoxidase in saliva of HIV-seropositive patients at different phases of HIV-infection. HIV-seronegative, healthy, age-matched patients served as controls. Saliva samples were characterized by Western blotting using antibodies specific for MMP-1, MMP-3 and MMP-8. Interstitial collagenase activities were measured using quantitative sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis/laser densitometry assay. Myeloperoxidase was analysed using quantitative dot blotting. Clinical and microbiological evaluation of HIV-seropositive patients' periodontium showed the presence of putative pe...Continue Reading

References

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Citations

Sep 26, 2002·Journal of Periodontology·Mark I Ryder
May 5, 2006·Advances in Dental Research·M UmadeviP G Robinson
Sep 14, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Liisa MellanenTimo Sorsa
Aug 23, 2012·Periodontology 2000·Mark I RyderJohn S Greenspan
Jan 14, 2004·Periodontology 2000·Sinem E Sahingur, Robert E Cohen
Dec 19, 2019·Periodontology 2000·Mark I RyderAnna-Barbara Moscicki

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