Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Katja AhokasUlpu Saarialho-Kere

Abstract

Matrix metalloproteinase 21 (MMP-21) and MMP-26 (matrilysin-2) are the two newest members of the human MMP gene family that have both been suggested to play an important role in epithelial tumor progression and to be regulated via the Wnt signaling pathway. We studied their expression in 34 esophageal squamous cell carcinomas and non-neoplastic epithelium. MMP-21 protein was detected in cancer cells and inflammatory cells at the invasive front. Its expression was associated with invasion, inflammation, apoptotic and well-differentiated areas of the tumors, but not with cell proliferation. Unlike MMP-21, MMP-26 protein was already upregulated in incipient invasion and its expression associated with regions of low differentiation being more sporadic at the invasive front. MMP-21 was detected basally in KYSE-30 and OE21 esophageal squamous cell carcinoma cells, while MMP-26 was absent. None of the several cytokines and matrices tested were capable of consistently upregulating MMP-21 or MMP-26 mRNA expression in these two cell lines. Our results suggest that during esophageal tumorigenesis, MMP-21 and MMP-26 have different, unique expression patterns both being tightly regulated and induced in the vicinity of inflammation. MMP-21 m...Continue Reading

References

Aug 1, 1997·The Journal of Investigative Dermatology·K AirolaU K Saarialho-Kere
May 29, 2000·European Journal of Biochemistry·A B de CoignacJ F Gauchat
Jul 18, 2002·The Journal of Biological Chemistry·Hyun I ParkQing-Xiang Amy Sang
Aug 8, 2002·The Journal of Investigative Dermatology·Ulpu Saarialho-KereJouko Lohi
Sep 5, 2002·Nature Reviews. Cancer·Christopher Mark Overall, Carlos López-Otín
Dec 25, 2002·Digestive Diseases and Sciences·Hirohi SaekiKeizo Sugimachi
Feb 15, 2003·The Journal of Biological Chemistry·Yun-Ge ZhaoQing-Xiang Amy Sang
Mar 6, 2003·The Biochemical Journal·George N MarchenkoAlex Y Strongin
Oct 1, 2003·Nature Genetics·Milagros BalbínCarlos López-Otín
Oct 22, 2003·Journal of Cancer Research and Clinical Oncology·S SamantarayR Ralhan
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Dec 24, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Katja AhokasUlpu Saarialho-Kere
Apr 8, 2004·International Journal of Cancer. Journal International Du Cancer·Keishi YamashitaMasaki Mori
Apr 9, 2005·The Journal of Investigative Dermatology·Katja AhokasUlpu Saarialho-Kere

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Citations

Nov 17, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Hong-Hua PengPei-Guo Cao
Jul 16, 2009·Experimental Dermatology·Sonja BoydUlpu Saarialho-Kere
Sep 21, 2006·Experimental Dermatology·Tiina SkoogUlpu Saarialho-Kere
Sep 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ville BisterUlpu Saarialho-Kere
Nov 19, 2009·Virchows Archiv : an International Journal of Pathology·Sari SuomelaUlpu Saarialho-Kere

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