Matrix metalloproteinases and cellular motility in development and disease

Birth Defects Research. Part C, Embryo Today : Reviews
Michael N VanSaun, L M Matrisian

Abstract

The movement of cells and the accompanied remodeling of the extracellular matrix is a critical step in many developmental processes. The matrix metalloproteinases (MMPs) are well recognized as mediators of matrix degradation, and their activity as regulators of signaling pathways by virtue of the cleavage of nonmatrix substrates has been increasingly appreciated. In this review, we focus on the role of MMPs in altering processes that influence cellular motility. MMP involvement in cellular adhesion, lamellipodia-directed movement, invadopodial protrusion, axonal growth cone extension, and chemotaxis are discussed. Although not designed to be comprehensive, these examples clearly demonstrate that cellular regulation of the MMPs influences cell motility in a variety of ways, including regulating cell-cell interactions, cell-matrix interactions, matrix degradation, and the release of bioactive signaling molecules. Deregulation of these interactions can ultimately result in disorders including inflammatory diseases, vascular diseases, bone diseases, neurological disorders, and cancer.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H E Van Wart, H Birkedal-Hansen
Jul 1, 1987·Journal of Cellular Biochemistry·M J WheelockC H Damsky
Aug 3, 1971·Biochemistry·E HarperJ Gross
Jun 1, 1995·Current Opinion in Structural Biology·W Stöcker, W Bode
Dec 1, 1994·American Journal of Respiratory and Critical Care Medicine·F Willenbrock, G Murphy
Oct 1, 1995·Protein Science : a Publication of the Protein Society·J W BeckerJ D Hermes
Jun 21, 1996·The Journal of Biological Chemistry·A ItoY Mori
Jan 1, 1997·Advances in Cancer Research·D NaorD Ish-Shalom
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·H NakaharaW T Chen
Nov 5, 1997·Experimental Cell Research·D C von BredowA E Cress
May 30, 1998·The Journal of Biological Chemistry·M W OlsonR Fridman
Feb 9, 2000·The Journal of Cell Biology·N KoshikawaV Quaranta
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Feb 7, 2001·Journal of the National Cancer Institute·M Hidalgo, S G Eckhardt
Feb 15, 2001·Seminars in Cancer Biology·I Stamenkovic
May 31, 2001·The Journal of Cell Biology·M KajitaM Seiki
Aug 4, 2001·The American Journal of Pathology·B StixC Röcken
Sep 7, 2001·Current Opinion in Cell Biology·L J McCawley, L M Matrisian
Sep 26, 2001·The Journal of Biological Chemistry·G A McQuibbanC M Overall
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·J C Rodriguez-ManzanequeM L Iruela-Arispe
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Dec 26, 2001·Chemical Reviews·M WhittakerA J Gearing

❮ Previous
Next ❯

Citations

Jan 29, 2010·European Journal of Orthodontics·Richard G JansenJohannes W Von den Hoff
Nov 4, 2008·Biological Chemistry·Elena Roza Motrescu, Marie-Christine Rio
Sep 24, 2010·Experimental Lung Research·Anita I SenJeanine M D'Armiento
Aug 5, 2015·Journal of Forensic Sciences·Yenan WangFukumi Furukawa
Nov 19, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Xi Ling LiuLi Wu Zheng
Sep 27, 2008·Molecular and Cellular Neurosciences·Hideo KobayashiVeronica I Shubayev
Dec 7, 2007·Fertility and Sterility·Sachiho NetsuMitsuaki Suzuki
Jun 9, 2007·Journal of Neuroimmunology·E A MilwardK Conant
May 1, 2007·Biophysical Journal·Sébastien Giraudier, Véronique Larreta-Garde
Feb 22, 2008·Muscle & Nerve·Cristiane BaniThereza Quirico-Santos
Sep 6, 2007·Journal of Cellular Physiology·Hong-Yun Li, Xin-Fu Zhou
Apr 4, 2008·Journal of Cellular Biochemistry·Corinne SchiltzValerie Geoffroy
Jan 30, 2008·European Journal of Clinical Investigation·I D PousaJ P Gisbert
Feb 11, 2011·Journal of Cellular and Molecular Medicine·Angelique A M van OorschotMarie-José Goumans
Sep 15, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexandre Bruni-CardosoHernandes F Carvalho
Jun 25, 2009·International Journal of Cancer. Journal International Du Cancer·Mary Jo MurnaneJohn B Willett
Jan 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexandre Bruni-CardosoHernandes F Carvalho
Aug 25, 2015·Genetic Testing and Molecular Biomarkers·Liu TaoKong Chuize
Oct 10, 2006·Veterinary Immunology and Immunopathology·Tzu-Yin Lin, Cheryl A London
Nov 9, 2010·Mechanisms of Development·Karl-Frederik BergeronBruce P Brandhorst
Aug 14, 2012·Neurobiology of Disease·Hala S Alameddine
Jul 18, 2009·Molecular and Cellular Neurosciences·Zuzana SiskováWia Baron
Nov 6, 2012·Developmental Biology·Sonja J McKeownRichard B Anderson
Jul 20, 2011·General and Comparative Endocrinology·Fernanda C A SantosSebastião R Taboga
Sep 13, 2016·International Journal of Molecular Sciences·Tonya R Ellis, Bryan D Crawford
Apr 9, 2009·Reproductive Sciences·Miltiadis Pitsos, Nikolaos Kanakas
Jul 1, 2011·Molecular Biology Reports·Li-Feng ZhangJian-Gang Zou
Jun 13, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Konstantinos KotronisGrigorios Grimbizis
Mar 18, 2015·Hormone Molecular Biology and Clinical Investigation·Marie-Christine RioCatherine Tomasetto
Jul 12, 2017·Frontiers in Physiology·Claire E L SmithAlan J Mighell
Jan 11, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tanya AggarwalElena N Kozlova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Cancer Metastasis Reviews
Elena I Deryugina, James P Quigley
Frontiers in Bioscience : a Journal and Virtual Library
Charles J Malemud
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Peter H LarsenV Wee Yong
© 2022 Meta ULC. All rights reserved