PMID: 9534207Apr 16, 1998Paper

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in giant cell arteritis: an immunocytochemical study

Pathology
Tatsuo Tomita, K Imakawa

Abstract

Giant cell arteritis (GCA) is a relatively common granulomatous arteritis of unknown etiology which mainly occurs in elderly people. Using histopathological findings from-seven biopsy cases of temporal artery and one autopsy case of GCA, and performing immunocytochemical staining for matrix metalloproteinase (MMP)-2 and -9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 and -2, we tested the hypothesis that an imbalance between MMPs and TIMPs may be a critical determinant in developing severe intimal hyperplasia and luminal stenosis. All biopsy cases revealed nearly complete luminal occlusion of the temporal artery with active lymphocytic infiltrate, fragmentation of internal lamina and median elastic fibers. Four of seven cases revealed typical GCA. The autopsy case was systematically sampled for histological examination, revealing GCA in the ascending aorta, main branches of aorta and coronary artery. Immunocytochemical staining revealed intense staining for MMP-2 and -9 in fragmented media of the aorta and artery, and less positive staining for TIMP-1 and -2 at the MMP-positive media. In situ hybridization revealed intense positive staining for TIMPs in GCA despite weak immunocytochemical staining for TIMPs. Contro...Continue Reading

References

Aug 1, 1991·Clinical Science·N Vine, J T Powell
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M HenneyS Humphries
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler

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Citations

Nov 26, 2002·Journal of Neuroimmunology·Eric V YangRonald Glaser
Sep 12, 2000·International Journal of Cardiology·M B Gravanis
Jul 8, 2011·The British Journal of Nutrition·Sun-Joong KimHyo Ihl Chang
Jan 13, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W C Parks
Apr 12, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·A J Bailey
Sep 9, 2009·Rheumatology·Alicia Rodríguez-PlaMark J Soloski
Jul 12, 2013·Rheumatology·F David CarmonaJavier Martín
May 16, 2007·Annals of the Rheumatic Diseases·Marta SegarraMaria C Cid
May 25, 2001·Analytical Biochemistry·W H Yu, J F Woessner
Mar 29, 2014·Cancers·Mohammed AbbaHeike Allgayer
Mar 22, 2002·Progress in Retinal and Eye Research·Jeremy M Sivak, M Elizabeth Fini
Sep 23, 2008·La Revue de médecine interne·L ArnaudZ Amoura
Mar 19, 2013·PloS One·Nina E Lamash, Igor Yu Dolmatov
Jan 25, 2014·Osteoarthritis and Cartilage·I N MelasL G Alexopoulos
Sep 25, 2014·Biochemical and Biophysical Research Communications·Da HuangJianghua Shao
Jul 7, 2005·Circulation·Alicia Rodríguez-PlaMiquel Vilardell-Tarres
Sep 28, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eric A AndreasenRobert L Tanguay
Aug 11, 2018·The EMBO Journal·Francesca TuortoFrank Lyko
Nov 13, 2014·Expert Review of Clinical Immunology·Victoria R DarlingDevendra K Agrawal
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sanjay GuptaHasan Mukhtar
Mar 18, 2004·La Presse médicale·Thierry GénéreauJean Cabane

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