Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head

Archives of Ophthalmology
X YanD P Edward

Abstract

To study expression and location of matrix metalloproteinases (MMPs) and tumor necrosis factor alpha (TNF-alpha) in glaucomatous optic nerve heads, which are known to be secreted in response to a variety of neuronal injury. Four postmortem eyes from patients with primary open-angle glaucoma, 7 eyes from patients with normal-pressure glaucoma, and 4 eyes from age-matched normal donors were studied by immunohistochemistry. The sections of the optic nerve heads were examined after immunostaining with antibodies to MMPs (MMP-1, MMP-2, and MMP-3), TNF-alpha, or TNF-alpha receptor 1. The intensity of the immunostaining and the number of stained cells for MMPs, TNF-alpha, or TNF-alpha receptor 1 were greater in the glaucomatous optic nerve heads, particularly in eyes with normal-pressure glaucoma compared with age-matched controls. Positive immunostaining was observed in all regions of the glaucomatous optic nerve heads, but most prominently in the postlaminar region. Immunostaining was observed mainly in glial cells and their processes around the axons and blood vessels and in pial septae. There is increased immunostaining for MMPs, TNF-alpha and TNF-alpha receptor 1 in the glaucomatous optic nerve head, which suggests increased expr...Continue Reading

Citations

Sep 26, 2013·BioMed Research International·Subhadip ChakrabortyKunal Ray
Jul 25, 2012·Indian Journal of Ophthalmology·Renu Agarwal, Puneet Agarwal
Jul 31, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shahid HusainCraig E Crosson
Mar 13, 2009·The New England Journal of Medicine·Young H KwonWallace L M Alward
Jun 16, 2009·Journal of Glaucoma·Elaine C Johnson, John C Morrison
Jul 4, 2009·Indian Journal of Ophthalmology·Renu AgarwalShyam S Agrawal
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Frédéric Lebrun-JulienPhilip A Barker
Jun 1, 2010·Journal of Ocular Biology, Diseases, and Informatics·Irina SurguchevaAndrei Surguchov
Aug 13, 2009·Journal of Ocular Biology, Diseases, and Informatics·Lori M Ventura
Jan 5, 2010·Journal of Ocular Biology, Diseases, and Informatics·Lori M Ventura
Mar 22, 2002·Progress in Retinal and Eye Research·Jeremy M Sivak, M Elizabeth Fini
Nov 20, 2012·Human Genomics·Eman ElhawyJohn Danias
Aug 1, 2006·Ophthalmic Epidemiology·Hossein Bahrami
Jul 2, 2005·Expert Opinion on Emerging Drugs·Abbot F Clark, Iok-Hou Pang
Nov 20, 2014·Journal of Neuroinflammation·Caitlin E Mac NairRobert W Nickells
Feb 24, 2016·Mediators of Inflammation·Mary K Wirtz, Kate E Keller
Jul 17, 2009·Journal of Neuropathology and Experimental Neurology·Yasushi KitaokaTim T Lam
Nov 8, 2008·Mayo Clinic Proceedings·E Andrew WallerJoseph Kaplan
Sep 18, 2015·Journal of Neuroinflammation·Gina N WilsonSamuel D Crish
May 18, 2011·Clinical & Experimental Ophthalmology·Banu BozkurtIlhan Tezcan
Apr 8, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Deborah M WallaceColm J O'Brien
Mar 8, 2013·Bioscience Reports·Ming-Hui YangYu-Chang Tyan
Apr 13, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yasushi KitaokaHitoshi Takagi
Jun 14, 2016·BioMed Research International·Rosa de HozJosé M Ramírez
Jul 19, 2016·Ophthalmic Genetics·Miao HeWenyong Huang
Aug 1, 2016·Immunologic Research·Maria Ida RizzoMarco de Vincentiis
Aug 26, 2014·Neuroscience Letters·Kaori KojimaHitoshi Takagi
Jun 15, 2016·Experimental Eye Research·Kate E Keller, Mary K Wirtz
Dec 6, 2007·Survey of Ophthalmology·Matthias C Grieshaber, Josef Flammer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.