Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms

Vascular Health and Risk Management
Thomas P VacekSuresh C Tyagi

Abstract

Atherosclerosis is an inflammatory process that involves activation of matrix metalloproteinases (MMPs); MMPs degrade collagen and allow for smooth-muscle cell migration within a vessel. Moreover, this begets an accumulation of other cellular material, resulting in occlusion of the vessel and ischemic events to tissues in need of nutrients. Homocysteine has been shown to activate MMPs via an increase in oxidative stress and acting as a signaling molecule on receptors like the peroxisome proliferator activated receptor-γ and N-methyl-D-aspartate receptor. Nitric oxide has been shown to be beneficial in some cases of deactivating MMPs. However, in other cases, it has been shown to be harmful. Further studies are warranted on the scenarios that are beneficial versus destructive. Hydrogen sulfide (H2S) has been shown to decrease MMP activities in all cases in the literature by acting as an antioxidant and vasodilator. Various MMP-knockout and gene-silencing models have been used to determine the function of the many different MMPs. This has allowed us to discern the role that each MMP has in promoting or alleviating pathological conditions. Furthermore, there has been some study into the MMP polymorphisms that exist in the populati...Continue Reading

Citations

Apr 2, 2016·Gastroenterology Research and Practice·Katarzyna JakubowskaKatarzyna Guzińska-Ustymowicz
Feb 4, 2016·Oxidative Medicine and Cellular Longevity·Yaqian HuangHongfang Jin
Jul 15, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wen-Jun WangJian Zhang
Dec 23, 2016·International Journal of Experimental Pathology·Christina Maria StegerThomas Schachner
Mar 25, 2019·Journal of Cardiovascular Pharmacology and Therapeutics·Marianna StasinopoulouJohn Kakisis
Dec 17, 2015·Nature Reviews. Neurology·Amanda M CarpenterCharles J Prestigiacomo
Nov 7, 2019·The Journal of Infectious Diseases·Han Sol LeeWoo Joo Kim
Feb 15, 2020·International Journal of Molecular Sciences·Verónica Guarner-LansIsrael Pérez-Torres
Oct 12, 2018·Cardiovascular Diabetology·Xiao-Yan QiZhi-Sheng Jiang
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Qin Yang, Guo-Wei He
Jul 15, 2017·Drug Delivery and Translational Research·Sannette Hall, Devendra K Agrawal
Dec 20, 2019·The Journal of International Medical Research·Wenjia ZhangShuhong Tang
Mar 7, 2020·Journal of Cardiovascular Translational Research·Alberto CecconiBorja Ibañez
Sep 5, 2018·International Journal of Molecular Sciences·Ashfaq AhmadJoseph K Ritter
Feb 8, 2019·Journal of Cellular and Molecular Medicine·Anna Krzywonos-ZawadzkaIwona Bil-Lula
Jun 4, 2019·Frontiers in Cardiovascular Medicine·Blaž BurjaMojca Frank-Bertoncelj
Mar 22, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Michael J HughesElizabeth Sapey
May 28, 2020·Reviews in Endocrine & Metabolic Disorders·Thalijn L C WoltersRomana T Netea-Maier
Dec 22, 2019·International Journal of Molecular Sciences·Norihiko Sasaki, Masashi Toyoda
Mar 12, 2019·Frontiers in Cellular Neuroscience·Guodong XuHong Sun
Oct 9, 2020·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A DievernichU Klinge
Dec 1, 2020·International Heart Journal·Tsukasa Oshima, Katsuhito Fujiu
Dec 4, 2020·Journal of Drug Targeting·Yin-Yu ZhangLi Qin
Jan 7, 2021·The FEBS Journal·Wesam BassiouniRichard Schulz
Dec 3, 2020·Atherosclerosis·Akhil KonkothFrancoise Dignat-George
Jan 8, 2021·Chinese Medical Journal·Lin LiuJia-Wei Liao
Aug 2, 2020·Molecular Aspects of Medicine·Yi Zhu, Gerald W Hart
Jul 3, 2021·Journal of Personalized Medicine·Yana V PolonskayaYulia I Ragino
Aug 25, 2021·Nitric Oxide : Biology and Chemistry·Jiechun Zhu, Guangdong Yang

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Methods Mentioned

BETA
transfection
gene-knockout

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