PMID: 8594211Oct 1, 1995Paper

Matrix metalloproteinases in brain injury

Journal of Neurotrauma
G A Rosenberg

Abstract

Proteolytic remodeling of the extracellular matrix occurs normally during development and pathologically in arthritis, tumor metastasis, wound healing, and angiogenesis. The major extracellular matrix-degrading proteinases belong to the matrix metalloproteinase (MMP) and plasminogen activator gene families. Intracerebral injection of 72-kDa type IV collagenase (gelatinase A) opens the blood-brain barrier. During hemorrhagic brain injury or intracerebral injection of proinflammatory cytokines, endogenous production of 92-kDa type IV collagenase (gelatinase B) occurs. The gelatinase B gene contains a phorbol ester responsive region (TRE) that binds AP-1 proteins, including c-Fos/c-Jun dimer, the early immediate response gene products. Maximum production of gelatinase B in injury occurs between 16 and 24 h, making this a late effector gene. The serine proteinase, urokinase-type plasminogen activator (uPA), is also produced at that time. Gelatinases and plasminogen activators work in concert to disrupt basement membranes proteolytically. A similar process opens the blood-brain barrier after ischemic and hemorrhagic brain injury, leading to secondary vasogenic brain edema. Delayed damage by proteolytic cascade enzymes provides oppor...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W CammerS Gordon
Dec 1, 1975·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I Montfort, R Pérez-Tamayo
Feb 1, 1975·The Journal of Experimental Medicine·H M Wisniewski, B R Bloom
Oct 2, 1975·The New England Journal of Medicine·R A Fishman
Apr 3, 1992·Brain Research·G A RosenbergW G Stetler-Stevenson
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·G A RosenbergW T Kyner
Feb 1, 1991·Journal of Neuroscience Research·H LassmannW F Hickey
Apr 1, 1990·Trends in Genetics : TIG·L M Matrisian
May 1, 1990·Stroke; a Journal of Cerebral Circulation·G A RosenbergM Kornfeld
Apr 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P D Yurchenco, J C Schittny
Aug 1, 1989·The Journal of Experimental Medicine·F M HofmanJ E Merrill
Jan 1, 1974·Folia primatologica; international journal of primatology·R I Dunbar, E P Dunbar
Nov 1, 1969·The Histochemical Journal·J F Hallpike, C W Adams
Nov 15, 1984·International Journal of Cancer. Journal International Du Cancer·J P McArdleW H Murphy
Jul 20, 1981·Brain Research·H Soreq, R Miskin
Sep 25, 1981·Science·A Krystosek, N W Seeds
May 1, 1981·Journal of Neuropathology and Experimental Neurology·H E HirschM E Parks
May 1, 1994·Analytical Biochemistry·D E Kleiner, W G Stetler-Stevenson
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·G A Rosenberg, M J Navratil
Jun 15, 1993·Journal of Neuroscience Research·C A ColtonW L Monsky

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Citations

Dec 3, 1999·Journal of Neuroscience Research·G PeridesM S Klempner
Aug 31, 2002·Glia·Gary A Rosenberg
Aug 9, 2012·Cellular and Molecular Neurobiology·Manao KinoshitaSchuichi Koizumi
Jan 18, 2013·Current Treatment Options in Neurology·Raphaella E Weiser, Kevin N Sheth
Jan 3, 2001·Brain Research·K KataokaP Carmeliet
Sep 3, 2002·Survey of Ophthalmology·Robert N WeinrebPaul L Kaufman
May 15, 2002·Brain Research. Molecular Brain Research·E M MuirJ H Rogers
Sep 24, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M TierneyS L Parsons
Apr 5, 2000·Progress in Retinal and Eye Research·M R Hernandez
Sep 11, 2003·Journal of Neurotrauma·Angela MuellnerGerhard F Hamann
Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S Mun-Bryce, G A Rosenberg
Jan 5, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M B Huang, V C Bond
Oct 27, 1999·Canadian Journal of Physiology and Pharmacology·M A ForgetR Béliveau
Feb 7, 2008·Neuro-Signals·Melissa D LairdKrishnan M Dhandapani
Aug 6, 2005·BMC Cancer·Nagi S El SaghirMukbil H Hourani
Jun 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hidekazu TanakaMizuo Miyazaki
Feb 28, 2004·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Mukundan G AtturAshok R Amin
Oct 16, 2004·Journal of Neurosurgery·Fatima A SehbaJoshua B Bederson
Jun 9, 2006·Neurological Research·Fatima A Sehba, Joshua B Bederson

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