Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking

PloS One
M KraenM Dencker

Abstract

Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. 450 middle-aged subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and -12. Due to missing data 33 subjects were excluded. The remaining 417 participants were divided into 4 different groups. Group I (n = 157, no plaque and no COPD), group II (n = 136, plaque but no COPD), group III (n = 43, COPD but no plaque) and group IV (n = 81, plaque and COPD). Serum levels of MMP-1,-7,-10-12 were significantly influenced by smoking, and MMP-1, -3, -7 and-12 were elevated in subjects with COPD and carotid plaque. This remained statistically significant for MMP-1 and-12 after adjusting for traditional risk factors....Continue Reading

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Citations

Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Loganathan RangasamyBeatriz de Pascual-Teresa
Sep 7, 2019·International Journal of Molecular Sciences·Botond SzucsJanos T Varga
Aug 1, 2019·Molecular Diagnosis & Therapy·Mario CazzolaPaola Rogliani
Sep 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Woodys Lenga Ma BondaPascale Reverdiau

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Methods Mentioned

BETA
lavage
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SPSS Statistics

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