Abstract
Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. 450 middle-aged subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and -12. Due to missing data 33 subjects were excluded. The remaining 417 participants were divided into 4 different groups. Group I (n = 157, no plaque and no COPD), group II (n = 136, plaque but no COPD), group III (n = 43, COPD but no plaque) and group IV (n = 81, plaque and COPD). Serum levels of MMP-1,-7,-10-12 were significantly influenced by smoking, and MMP-1, -3, -7 and-12 were elevated in subjects with COPD and carotid plaque. This remained statistically significant for MMP-1 and-12 after adjusting for traditional risk factors....Continue Reading
References
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·K ImaiJ D'Armiento
May 26, 2001·The Journal of Clinical Investigation·V LemaîtreJ D'Armiento
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Mar 3, 2004·Circulation·Aernout LuttunLieve Moons
Apr 10, 2004·Stroke; a Journal of Cerebral Circulation·Angharad R MorganShu Ye
May 10, 2005·Respiratory Medicine·S V CulpittL E Donnelly
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jason L JohnsonChristopher L Jackson
Feb 9, 2008·COPD·Alison M WallaceRaja T Abboud
Jul 12, 2008·American Journal of Respiratory Cell and Molecular Biology·Becky A MercerJeanine M D'Armiento
Dec 24, 2010·The European Respiratory Journal·S LöffekC-W Franzke
Apr 21, 2011·BMC Pulmonary Medicine·Helen IlumetsVuokko L Kinnula
May 14, 2011·The European Respiratory Journal·A DaveyC M O'Kane
Jun 8, 2011·Nucleic Acids Research·Martin LundbergSimon Fredriksson
Sep 17, 2011·The European Respiratory Journal·A ChurgJ L Wright
Feb 3, 2012·Clinical Physiology and Functional Imaging·Sophia FrantzPer Wollmer
Feb 7, 2012·The Journal of Allergy and Clinical Immunology·Rekha ChaudhuriNeil C Thomson
May 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Zdenka NavratilovaMartin Petrek
May 23, 2012·Respiratory Medicine·S FrantzP Wollmer
Feb 27, 2013·PloS One·Jeanine M D'ArmientoRobert F Foronjy
Apr 23, 2013·Mediators of Inflammation·Jodie L SimpsonPeter G Gibson
Jun 1, 2013·Chest·Hana MüllerovaDouglas W Mapel
Apr 24, 2014·PloS One·Erika AssarssonSimon Fredriksson
May 9, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Isabel GoncalvesUNKNOWN SUMMIT Consortium
Oct 8, 2015·Clinical Physiology and Functional Imaging·Per WollmerUlf Nihlén
Nov 28, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Zdenka NavratilovaMartin Petrek
Oct 19, 2016·Journal of Vascular Research·Jean Marie RuddyJeffrey A Jones
Sep 30, 2016·Atherosclerosis·Biying HuangErik Ingelsson
Apr 28, 2017·Cardiovascular Diabetology·S A PeetersC D A Stehouwer
Feb 7, 2018·Matrix Biology : Journal of the International Society for Matrix Biology·Sina A GharibWilliam C Parks
Sep 3, 2018·Journal of Molecular and Cellular Cardiology·Veronika A MyasoedovaAlexander N Orekhov
Citations
Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Loganathan RangasamyBeatriz de Pascual-Teresa
Sep 7, 2019·International Journal of Molecular Sciences·Botond SzucsJanos T Varga
Feb 27, 2020·Vaccines·Nandadeva LokugamageNisha Jain Garg
Aug 1, 2019·Molecular Diagnosis & Therapy·Mario CazzolaPaola Rogliani
Mar 5, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Lars LindAnders Mälarstig
Apr 6, 2021·Clinical Hemorheology and Microcirculation·Gregorio CaimiRosalia Lo Presti
Aug 5, 2021·Current Research in Toxicology·Lukasz CzekalaTanvir Walele
Sep 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Woodys Lenga Ma BondaPascale Reverdiau
Sep 30, 2021·Clinical Proteomics·K EgervallS Elmståhl
Dec 7, 2021·COPD·Amir TajbakhshAmir Abbas Momtazi-Borojeni