Matrix metalloproteinases in pro-atherosclerotic arterial remodeling

Journal of Molecular and Cellular Cardiology
Veronika A MyasoedovaAlexander N Orekhov

Abstract

Matrix metalloproteinases (MMPs) is a family of Zn2+ endopeptidases that process various components of the extracellular matrix. These enzymes are also involved in activation and inhibition of signaling cascades through proteolytic cleavage of surface receptors. Moreover, MMPs play a key role in tissue remodeling and and repair. Dysregulation of MMPs is observed in patholofgical conditions, including atherosclerosis, which is associated with hyperactivation of MMPs, aberrant tissue remodeling and neovascularization of the growing atherosclerotic plaques. This makes MMPs interesting therapeutic targets that can be employed for developing novel therapies to treat atherosclerosis and its complications. Currently, a growing number of synthetic MMP inhibitors is available. In this review, we will discuss the role of these enzymes in atherosclerosis pathology and the ways of their pothential therapeutic use.

Citations

Jan 3, 2020·Circulation Research·Gábor CsányiBrian H Annex
Mar 13, 2020·Journal of Translational Medicine·Wen JianChun Gui
Jun 30, 2019·Journal of Muscle Research and Cell Motility·TecLino AfewerkiDerek Warren
Jun 4, 2020·International Journal of Molecular Sciences·Wioletta OlejarzGrażyna Kubiak-Tomaszewska
Nov 30, 2019·Cellular Signalling·A Sainio, H Järveläinen
Feb 23, 2021·Frontiers in Cardiovascular Medicine·Yuling WuLijuan Zhang
Mar 31, 2021·The American Journal of the Medical Sciences·Jessica GablerSabine Eichinger

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