PMID: 9450622Feb 5, 1998Paper

Matrix metalloproteinases in skin

Experimental Dermatology
V M Kähäri, U Saarialho-Kere

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases collectively capable of degrading essentially all extracellular matrix components. These enzymes can be produced by several different types of cells in skin such as fibroblasts, keratinocytes, macrophages, endothelial cells, mast cells, and eosinophils and their activity can be specifically inhibited by TIMPs (tissue inhibitors of metalloproteinases), which bind to active MMPs with 1:1 stoichiometry. In general, MMPs are not constitutively expressed in skin but are induced temporarily in response to exogenous signals such as various cytokines, growth factors, cell matrix interactions and altered cell-cell contacts. At present, more evidence is accumulating that MMPs play an important role in proteolytic remodeling of extracellular matrix in various physiologic situations, including developmental tissue morphogenesis, tissue repair, and angiogenesis. On the other hand, MMPs play an important pathogenetic role in excessive breakdown of connective tissue components, e.g. in rheumatoid arthritis, osteoarthritis, chronic ulcers, dermal photoageing, and periodontitis, as well as in tumor cell invasion and metastasis. In this review we discuss the role of M...Continue Reading

References

Oct 1, 1977·The Journal of Investigative Dermatology·E A BauerA Z Eisen
Mar 1, 1992·Clinical & Experimental Metastasis·K R GehlsenP Sriramarao
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R E SeftorM J Hendrix
Oct 1, 1992·The Journal of Investigative Dermatology·M Ståhle-BäckdahlW C Parks
Nov 11, 1992·The Journal of Investigative Dermatology·L Bruckner-TudermanT Gedde-Dahl
Oct 30, 1992·Biochemical and Biophysical Research Communications·C GuerinH Brem
Jun 19, 1991·International Journal of Cancer. Journal International Du Cancer·D MullerJ Abecassis
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·L M GolubB R Rifkin
Jan 1, 1991·Archives of Dermatological Research·K ScharffetterG Plewig
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H E Van Wart, H Birkedal-Hansen
Oct 1, 1988·International Journal of Dermatology·K TakamoriH Ogawa
Jan 1, 1989·The Journal of Investigative Dermatology·J O WinbergE A Bauer
Jul 15, 1985·International Journal of Cancer. Journal International Du Cancer·J F Burman, R L Carter
Nov 1, 1986·The Journal of Investigative Dermatology·H G WelgusG P Stricklin
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WilhelmG I Goldberg
May 1, 1969·The Journal of Investigative Dermatology·A Z Eisen
Apr 1, 1974·The Journal of Investigative Dermatology·M E ReddickA Z Eisen
Dec 1, 1995·Journal of the American Academy of Dermatology·K KikuchiK Tamaki
Jun 1, 1994·The Journal of Investigative Dermatology·K A McGowanL T Smith
Jul 1, 1995·The Journal of Investigative Dermatology·T HaapalainenT Salo
Aug 1, 1995·The Journal of Investigative Dermatology·U K Saarialho-KereW C Parks
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·J JuarezD Boyd
Nov 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Bou-GhariosI Olsen
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A OkadaP Basset
May 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J KusukawaT Kameyama
Feb 1, 1995·The Journal of Investigative Dermatology·E C BullenE W Howard

❮ Previous
Next ❯

Citations

Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·P J BoströmM Laato
Mar 14, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Dror Ben-DavidAbraham Z Reznick
Jun 10, 2011·Archives of Dermatological Research·Young Mee LeeJin Ho Chung
Sep 16, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·Timothy R DonahueRonald W Busuttil
Oct 7, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·R RoschV Schumpelick
Apr 17, 2008·Angiogenesis·Payaningal R SomanathTatiana V Byzova
Jul 4, 2008·Breast Cancer Research and Treatment·S M EckC E Brinckerhoff
Jul 3, 2013·Journal of Neuro-oncology·Wen-Chiuan TsaiDueng-Yuan Hueng
Jan 5, 2007·Medical & Biological Engineering & Computing·I DigelA Temiz Artmann
Nov 11, 2009·Biological Trace Element Research·Florence Hazane-PuchIsabelle Hininger-Favier
Jun 5, 2004·Ageing Research Reviews·J Labat-Robert
Jun 1, 2005·Foot and Ankle Clinics·Merzesh Magra, Nicola Maffulli
Jul 14, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gregor M BranHaneen Sadick
May 24, 2003·Biochemical and Biophysical Research Communications·Giuseppe ValacchiCarroll E Cross
Feb 17, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M PendásC López-Otín
Dec 4, 2001·Fertility and Sterility·N CheginiUNKNOWN Peritoneal Healing and Adhesion Multiuniversity Study Group
Dec 4, 2001·Fertility and Sterility·N CheginiUNKNOWN Pritoneal Healing and Adhesion Multiuniversity Study Group
Jun 6, 2003·Journal of Molecular and Cellular Cardiology·Ravi Ramani, Charles F McTiernan
Oct 25, 2003·Toxicology and Applied Pharmacology·Nicholette A ZeliadtElizabeth V Wattenberg
Oct 9, 2002·Neuroscience and Biobehavioral Reviews·John W WrightJoseph W Harding
Mar 14, 2001·Journal of Biochemical and Biophysical Methods·B A Mungall, C C Pollitt
Mar 7, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M SassiJ Risteli
Jan 13, 2000·Clinics in Dermatology·S MorettiC Pinzi
Sep 6, 2001·Clinics in Geriatric Medicine·S KangJ J Voorhees
Feb 22, 2001·Free Radical Biology & Medicine·J FuchsM Podda
Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·A BertonG Bellon
Sep 28, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·L O NelimarkkaH T Järveläinen
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Benedetta CinqueM Grazia Cifone
Jul 19, 2000·Oral Oncology·B L ZioberR H Kramer
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Christopher LiColin Jamora
Feb 3, 2005·Photomedicine and Laser Surgery·Daniel LevanonAvi Ravid
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·S TodaH Sugihara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.