Matrix metalloproteinases play an active role in Wnt1-induced mammary tumorigenesis

Cancer Research
Laurence BlavierYves A DeClerck

Abstract

The Wnt signaling transduction pathway plays a critical role in the pathogenesis of several murine and human epithelial cancers. Here, we have used mouse mammary tumor virus (MMTV)-Wnt1 transgenic mice, which develop spontaneous mammary adenocarcinoma, to examine whether matrix metalloproteinases (MMPs)--a family of extracellular proteases implicated in multiple steps of cancer progression--contributed to Wnt1-induced tumorigenesis. An analysis of the expression of several MMPs by RT-PCR and in situ hybridization revealed an increase in the expression of MMP-2, MMP-3, MMP-9, MMP-13, and MT1-MMP (MMP-14) in hyperplastic glands and in mammary tumors of MMTV-Wnt1 transgenic mice. Interestingly, whereas MMP-2, MMP-3, and MMP-9 were exclusively expressed by stromal cells in mammary tumors, MMP-13 and MT1-MMP were expressed by transformed epithelial cells in addition to the tumor stroma. To determine whether these MMPs contributed to tumorigenesis, MMTV-Wnt1 mice were crossed with transgenic mice overexpressing tissue inhibitor of metalloproteinase-2-a natural MMP inhibitor-in the mammary gland. In the double MMTV-Wnt1/tissue inhibitor of metalloproteinases-2 transgenic mice, we observed an increase in tumor latency and a 26.3% reduc...Continue Reading

References

Jun 26, 1992·Cell·R Nusse, H E Varmus
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T C BooneK E Langley
Sep 1, 1994·Molecular and Cellular Biology·G T WongA P McMahon
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G M ShacklefordH E Varmus
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C L WilsonL M Matrisian
Apr 1, 1997·Trends in Genetics : TIG·R T MoonM Torres
Feb 7, 1998·Genes & Development·K M Cadigan, R Nusse
Sep 4, 1998·Science·T C HeK W Kinzler
Jul 23, 1999·Annals of the New York Academy of Sciences·L BlavierY A Declerck
Oct 26, 1999·Current Biology : CB·L M Matrisian
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R NelsonL M Matrisian
Mar 10, 2000·Biochimica Et Biophysica Acta·K BrewH Nagase
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Sep 7, 2001·Current Opinion in Cell Biology·L J McCawley, L M Matrisian
Mar 14, 2002·Biochemical and Biophysical Research Communications·Gianluigi GiannelliSalvatore Antonaci
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Christophe F ChantrainGeorge McNamara
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·N E SounniA Noel
Apr 30, 2003·Nature·Tannishtha ReyaIrving L Weissman
Jun 7, 2003·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Kasper Almholt, Morten Johnsen
Jul 31, 2003·Cell·Dong-Wan SeoWilliam G Stetler-Stevenson
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Jan 11, 2005·The Journal of Pathology·Mohammad Ilyas
Feb 25, 2005·International Journal of Cancer. Journal International Du Cancer·Madeleine M Handsley, Dylan R Edwards
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Apr 28, 2005·Journal of Cell Science·Christina H StueltenAnita B Roberts

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Citations

Feb 9, 2007·Journal of Mammary Gland Biology and Neoplasia·Kasper AlmholtJohn Rømer
May 25, 2007·Nature Reviews. Cancer·John D Potter
Jan 10, 2008·Annual Review of Cell and Developmental Biology·R Grant Rowe, Stephen J Weiss
Aug 21, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Rugmani Padmanabhan IyerMerry L Lindsey
Jul 19, 2006·Breast Cancer Research : BCR·Christine L Hattrup, Sandra J Gendler
Jun 6, 2008·World Journal of Gastroenterology : WJG·Xian-Min BuXian-Wei Dai
Aug 2, 2008·PPAR Research·James M PhangYongmin Liu
Jun 24, 2008·Critical Reviews in Clinical Laboratory Sciences·William Cruz-Munoz, Rama Khokha
Jul 22, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mert ErkanJörg Kleeff
Nov 11, 2008·Oral Diseases·E HannaS K Libutti
Aug 18, 2012·Stem Cells·Natesh ParashuramaSanjiv S Gambhir
Mar 23, 2011·Journal of Cellular and Molecular Medicine·Julie DecockDylan R Edwards
Oct 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonio MazzoccaGianluigi Giannelli
Jun 11, 2010·Cancer Biology & Therapy·Laurence BlavierYves A DeClerck
Dec 10, 2016·Nature Reviews. Cancer·Hartland W JacksonRama Khokha
Feb 7, 2008·The Journal of Pharmacology and Experimental Therapeutics·Olivia FromiguéPierre J Marie
Aug 4, 2007·The Journal of Biological Chemistry·Annie L EisingerDavid A Jones
May 22, 2007·The Journal of Nutrition·Neil E HubbardKent L Erickson
Mar 6, 2021·Molecular and Cellular Biochemistry·Mikako SaitoSeiya Minagawa
Apr 10, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·S Pauliina TurunenKaisa Lehti

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