Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts

Cytokine
Franco CavallaM Hernández

Abstract

Periodontitis is a highly prevalent infectious disease characterized by the progressive inflammatory destruction of tooth-supporting structures, leading to tooth loss. The underling molecular mechanisms of the disease are incompletely understood, precluding the development of more efficient screening, diagnostic and therapeutic approaches. We investigated the interrelation of three known effector mechanisms of the cellular response to periodontal infection, namely reactive oxygen species (ROS), matrix metalloproteinases (MMPs) and cytokines in primary cell cultures of human periodontal ligament fibroblast (hPDLF). We demonstrated that ROS increase the activity/levels of gelatinolytic MMPs, and stimulate cytokine secretion in hPDLF. Additionally, we proved that MMPs possesses immune modulatory capacity, regulating the secreted levels of cytokines in ROS-stimulated hPDLF cultures. This evidence provides further insight in the molecular pathogenesis of periodontitis, contributing to the future development of more effective therapies.

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Citations

Jul 13, 2017·Antioxidants & Redox Signaling·Britta Kunkemoeller, Themis R Kyriakides
Dec 28, 2017·Journal of Oral Science·Kazunori NakajimaTakashi Sawase
Sep 22, 2017·European Journal of Dentistry·Piero PapiGiorgio Pompa
Mar 2, 2017·Female Pelvic Medicine & Reconstructive Surgery·Bruna M CouriMargot S Damaser
Feb 22, 2017·International Journal of Molecular Sciences·Cavalla FrancoHernández Marcela
Mar 7, 2017·Clinical Oral Investigations·M Salinas-MuñozM Hernández
Nov 23, 2017·Frontiers in Physiology·Patricia Hernández-RíosMarcela Hernández
May 14, 2020·International Journal of Molecular Sciences·Yingzhi Gu, Xiaozhe Han
Sep 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria GreabuEcaterina Ionescu
Jul 3, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Teerasak DamrongrungruangAroonsri Priprem

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