Matrix metalloproteinases, tissue inhibitors of metalloproteinases, aminoterminal propeptide of procollagen type III, and hyaluronan in sera and tissue of patients with capsular contracture after augmentation with Trilucent breast implants

Plastic and Reconstructive Surgery
Dietmar UlrichNorbert Pallua

Abstract

In various fibrotic diseases, matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important role. In our study, serum concentrations of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined by enzyme-linked immunosorbent assay in 17 female patients with Baker grade II (n =9), III (n =7), and IV (n =1) capsular contracture after bilateral cosmetic mamma augmentation with Trilucent implants (AEI, Inc., Caversham, United Kingdom). Samples of capsular tissue for standard histology and immunohistochemistry were obtained from all patients. Sera from 20 female patients who had plastic surgery for reduction mammaplasty were used as the control group. The aminoterminal propeptide of procollagen type III (PIIINP) and hyaluronan were analyzed as markers for fibrogenesis in both groups, too. Statistical analysis was performed using the Mann-Whitney test and Spearman rank correlation. Patients with capsular contracture presented significantly higher concentrations of TIMP-1 and TIMP-2 in their sera than did the control group (p < 0.05), which correlated with Baker grade (r = 0.7 versus r = 0.65; p < 0.05). The concentration of MMP-2 was significantly higher in the ser...Continue Reading

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Citations

Mar 11, 2006·Aesthetic Plastic Surgery·Marco MazzocchiNicolò Scuderi
Sep 2, 2008·Archives of Orthopaedic and Trauma Surgery·Dietmar UlrichNorbert Pallua
Jul 2, 2009·Plastic and Reconstructive Surgery·Amy StumpRonald P Silverman
Dec 3, 2009·Plastic and Reconstructive Surgery·Antonino AracoGianpiero Gravante
Aug 24, 2011·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Dietmar UlrichNorbert Pallua
Apr 23, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Andri Maruli Tua Lubis, Vita Kurniati Lubis
Sep 8, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cornelia Katharina Mueller, Stefan Schultze-Mosgau
May 26, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Dietmar UlrichNorbert Pallua
Aug 15, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Daniel J T KyleArdeshir Bayat
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