Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease

Circulation
S Hinan AhmedMichael R Zile

Abstract

Chronic hypertension may cause left ventricular (LV) remodeling, alterations in cardiac function, and the development of chronic heart failure (CHF). Changes in the composition of the extracellular matrix (ECM) known to occur in hypertension are believed to be causally related to these structural, functional, and clinical outcomes. However, whether the determinants of ECM composition, such as the balance between ECM proteases (matrix metalloproteinases [MMPs]) and their tissue inhibitors [TIMPs]), are altered in hypertensive heart disease is unknown. Plasma MMP-2, -9, and -13 values, TIMP-1 and -2 values, and Doppler echocardiography images were obtained for 103 subjects divided into 4 groups: (1) reference subjects (CTL) with no evidence of cardiovascular disease, (2) hypertensive (HTN) subjects with controlled blood pressure and no LV hypertrophy, (3) hypertensive subjects with controlled blood pressure and with LV hypertrophy (HTN+LVH) but no CHF, and (4) hypertensive subjects with controlled blood pressure, LVH, and CHF (HTN+LVH+CHF). Compared with CTL, patients with HTN had no significant changes in any MMP or TIMP. Patients with HTN+LVH had decreased MMP-2 and MMP-13 values and increased MMP-9 values. Only patients with H...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
May 22, 1996·JAMA : the Journal of the American Medical Association·D LevyK K Ho
Mar 10, 2000·Biochimica Et Biophysica Acta·K BrewH Nagase
Jun 1, 2001·The Annals of Thoracic Surgery·C JoffsF G Spinale
Mar 23, 2002·Circulation Research·Francis G Spinale
Jun 27, 2002·Journal of the American College of Cardiology·Giuseppe SchillaciElmo Mannarino
Aug 3, 2002·Hypertension·M Mitchell LindsayFrancis G Dunn
Dec 11, 2002·Circulation·Donald M Lloyd-JonesUNKNOWN Framingham Heart Study
Jan 16, 2003·Journal of Cardiac Failure·Eric M WilsonFrancis G Spinale
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Sep 4, 2003·Annals of Medicine·Merry L LindseyFrancis G Spinale
Dec 9, 2003·American Journal of Physiology. Cell Physiology·Hong KanMitchell S Finkel
Jan 24, 2004·Heart Failure Reviews·Toshihiro TsurudaJohn C Burnett
Feb 12, 2004·The Medical Clinics of North America·Satish Kenchaiah, Marc A Pfeffer

❮ Previous
Next ❯

Citations

Nov 9, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Diogo M O MarçalJose E Tanus-Santos
Aug 21, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Ashraf TayeOmar M M Mohafez
Mar 19, 2008·Basic Research in Cardiology·Sophie Van LinthoutCarsten Tschöpe
Dec 2, 2009·Current Heart Failure Reports·Jean G F Bronzwaer, Walter J Paulus
Apr 9, 2013·Current Heart Failure Reports·Samuel W Joffe, Robert A Phillips
May 30, 2013·Journal of Cardiovascular Translational Research·Michael R Zile, Catalin F Baicu
Mar 8, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Soo-Jin KangJoon-Han Shin
Sep 20, 2005·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A CordovaF Moschella
Oct 28, 2010·Cardiology in the Young·Tain-Yen HsiaFrancis G Spinale
Dec 13, 2012·Journal of Exposure Science & Environmental Epidemiology·Jefferey L BurgessRobin B Harris
Nov 28, 2008·Journal of Human Hypertension·G W YipJ E Sanderson
Mar 16, 2012·Journal of Human Hypertension·V J KarthikeyanA D Blann
Jun 11, 2008·Nature Clinical Practice. Cardiovascular Medicine·Maral OuzounianPeter P Liu
Jan 17, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W KosmalaW Mazurek
Oct 7, 2008·Cardiovascular Research·Karl T WeberRobert U Simpson
Mar 26, 2013·Cardiovascular Research·Ratnadeep BasuZamaneh Kassiri
Dec 9, 2010·European Heart Journal·Barry A Borlaug, Walter J Paulus
Oct 3, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadezda KoleganovaMarie-Luise Gross
Dec 27, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Belinda SpotoCarmine Zoccali
Feb 21, 2013·Cardiology in Review·Dimitry A ChistiakovAlexander N Orekhov
Jun 4, 2008·Journal of Cardiovascular Pharmacology·Maurizio Galderisi, Oreste de Divitiis
Mar 23, 2011·Journal of Cardiovascular Pharmacology·Sanne de JongHarold V M van Rijen
Aug 27, 2010·Clinical and Experimental Pharmacology & Physiology·Kaoru KimuraMasafumi Kuzuya
Nov 24, 2012·American Journal of Physiology. Cell Physiology·Edie C GoldsmithFrancis G Spinale
Mar 3, 2007·The Journal of Clinical Investigation·Bradford C BerkStephanie Lehoux
Aug 22, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takayuki Ito

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.