Maturation- and sex-sensitive depression of hippocampal excitatory transmission in a rat schizophrenia model

Brain, Behavior, and Immunity
Eti PatrichBernard Attali

Abstract

Schizophrenia is associated with behavioral and brain structural abnormalities, of which the hippocampus appears to be one of the most consistent region affected. Previous studies performed on the poly I:C model of schizophrenia suggest that alterations in hippocampal synaptic transmission and plasticity take place in the offspring. However, these investigations yielded conflicting results and the neurophysiological alterations responsible for these deficits are still unclear. Here we performed for the first time a longitudinal study examining the impact of prenatal poly I:C treatment and of gender on hippocampal excitatory neurotransmission. In addition, we examined the potential preventive/curative effects of risperidone (RIS) treatment during the peri-adolescence period. Excitatory synaptic transmission was determined by stimulating Schaffer collaterals and monitoring fiber volley amplitude and slope of field-EPSP (fEPSP) in CA1 pyramidal neurons in male and female offspring hippocampal slices from postnatal days (PNDs) 18-20, 34, 70 and 90. Depression of hippocampal excitatory transmission appeared at juvenile age in male offspring of the poly I:C group, while it expressed with a delay in female, manifesting at adulthood. I...Continue Reading

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Citations

Jan 20, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gurudutt PendyalaAnna Dunaevsky
Jun 20, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marie-Julie AllardGuillaume Sebire
Feb 16, 2019·Translational Psychiatry·Pierluca Coiro, Daniela D Pollak
Jul 1, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yucen XiaYongjun Chen
May 11, 2019·International Journal of Molecular Sciences·Maryam ArdalanCarina Mallard
Jan 30, 2021·Translational Psychiatry·Serena Banu GumusogluHanna Elizabeth Stevens

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