Maturation of collagen fibril network structure in tibial and femoral cartilage of rabbits

Osteoarthritis and Cartilage
P JulkunenH J Helminen

Abstract

The structure and composition of articular cartilage change during development and growth, as well as in response to varying loading conditions. These changes modulate the functional properties of cartilage. We studied maturation-related changes in the collagen network organization of cartilage as a function of tissue depth. Articular cartilage from the tibial medial plateaus and femoral medial condyles of female New Zealand white rabbits was collected from six age-groups: 4 weeks (n=30), 6 weeks (n=30), 3 months (n=24), 6 months (n=24), 9 months (n=27) and 18 months (n=19). Collagen fibril orientation, parallelism (anisotropy) and optical retardation were analyzed with polarized light microscopy. Differences in the development of depth-wise collagen organization in consecutive age-groups and the two joint locations were compared statistically. The collagen fibril network of articular cartilage undergoes significant changes during maturation. The most prominent changes in collagen architecture, as assessed by orientation, parallelism and retardation were noticed between the ages of 4 and 6 weeks in tibial cartilage and between 6 weeks and 3 months in femoral cartilage, i.e., orientation became more perpendicular-to-surface, and...Continue Reading

References

Sep 1, 1991·The Journal of Bone and Joint Surgery. British Volume·A K JefferyG Bentley
Oct 1, 1994·British Journal of Rheumatology·J P Urban
Feb 1, 1994·International Journal of Oral and Maxillofacial Surgery·W C PuelacherC A Vacanti
Dec 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Muir
May 20, 1999·Journal of Biomedical Materials Research·J P ArokoskiJ S Jurvelin
May 16, 2000·Journal of Biomechanics·J S JurvelinH J Helminen
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M T NieminenJ S Jurvelin
Mar 12, 2002·Medical Engineering & Physics·R K KorhonenJ S Jurvelin
Jul 11, 2002·Equine Veterinary Journal·P A J BramaP R van Weeren
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stephen D WaldmanRita A Kandel
Jun 8, 2004·Journal of Biomechanical Engineering·Hui Jin, Jack L Lewis
Jun 23, 2005·Osteoarthritis and Cartilage·Thomas M QuinnHans-Jörg Häuselmann
Mar 4, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Panu KivirantaJukka S Jurvelin
Nov 1, 2006·NMR in Biomedicine·Wilfried Gründer
Jul 17, 2007·Medical Engineering & Physics·Petro JulkunenJukka S Jurvelin
Sep 25, 2007·Seminars in Arthritis and Rheumatism·Yang Xia
Jan 29, 2008·Osteoarthritis and Cartilage·P KivirantaJ S Jurvelin
Apr 23, 2008·Pediatric Research·Gregory M WilliamsRobert L Sah
Feb 27, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Pieter A J BramaMika M Hyttinen
Jan 1, 2007·Critical Reviews in Biomedical Engineering·Donald J ResponteKyriacos A Athanasiou
Jun 23, 2009·Ultrasound in Medicine & Biology·Panu KivirantaJukka S Jurvelin

❮ Previous
Next ❯

Citations

Oct 26, 2010·BMC Developmental Biology·Mark C van TurnhoutJohan L van Leeuwen
Jun 10, 2010·BMC Developmental Biology·Mark C van TurnhoutJohan L van Leeuwen
Jun 8, 2010·Biomechanics and Modeling in Mechanobiology·Mark C van TurnhoutJohan L van Leeuwen
May 8, 2013·The Veterinary Journal·Sheila Laverty, Christiane Girard
Dec 10, 2014·Anatomia, histologia, embryologia·M Kobayashi-MiuraY Fujita
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·June E JeonDietmar W Hutmacher
Aug 17, 2011·Osteoarthritis and Cartilage·R MahmoodianS Siegler
Oct 9, 2014·BioMed Research International·Katie H SizelandRichard G Haverkamp
Jan 26, 2020·Cells·I Collins, A K T Wann
Dec 31, 2019·Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization·Milad RakhshaDan Negrut
Apr 24, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Shannon K WalshCorinne R Henak
Dec 17, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eng Kuan MooWalter Herzog

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.