Maturation of dendritic cells by bacterial immunomodulators

Vaccine
Radek SpísekJirina Bartunkova

Abstract

Dendritic cells (DC) become fully functional upon maturation by various stimuli. We tested whether an immunostimulatory effect of clinically used immunomodulators (Luivac, Biostim, Ribomunyl, Imudon, Bronchovaxom) is caused by direct DC activation. We found that Luivac, Biostim and Ribomunyl have a very high DC stimulatory potential in vitro. The level of DC activation was comparable or higher than DC maturation induced by standard maturation stimuli, Poly (I:C) or lipopolysaccharide. Treated DC had activated phenotype, reduced phagocytic activity and they induced the proliferation of allogeneic T lymphocytes. These results are important for understanding the physiology of action of these widely prescribed agents. Administration of bacterial immunomodulators should be considered with care to avoid the potential risk of inducing an autoimmune disease. They could also be used as well-defined maturating agents in the protocols used for the ex vivo production of DC-based vaccines for clinical trials.

References

Jun 3, 2000·Annual Review of Immunology·L Fong, E G Engleman
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Feb 24, 2001·The Journal of Experimental Medicine·M V DhodapkarN Bhardwaj
Jun 29, 2001·Trends in Immunology·H JonuleitA H Enk
Aug 18, 2001·Cell·A Lanzavecchia, F Sallusto
Mar 20, 2002·The Journal of Experimental Medicine·Michel Gilliet, Yong-Jun Liu
Mar 22, 2002·Nature Reviews. Immunology·R Medzhitov
Apr 2, 2002·Journal of Immunotherapy·Claire BoccaccioAlessandra Nardin
Jun 27, 2003·Cancer Immunology, Immunotherapy : CII·Dorian McIlroy, Marc Gregoire
Mar 11, 2009·Human Gene Therapy·Xiaopei Huang, Yiping Yang

❮ Previous
Next ❯

Citations

Jan 3, 2012·Journal of Translational Medicine·Jitka FučíkováRadek Špíšek
May 16, 2007·Cancer Immunology, Immunotherapy : CII·Sandra TuyaertsAude Bonehill
Sep 21, 2010·Cellular Immunology·Ondřej SuchánekPavel Kolář
Jun 26, 2007·International Journal of Medical Microbiology : IJMM·Catur RianiAndreas Podbielski
Jul 27, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Elizabeth P St JohnGregory T Spear
Oct 25, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zuzana TobiásováJirina Bartůnková
Jun 13, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniela RozkovaRadek Spisek
Jan 27, 2006·European Journal of Pharmacology·Wojciech FeleszkoEckard Hamelmann
Jul 29, 2010·Vaccine·Katerina SkalovaJaroslav Michalek
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andy K W HsuAlison M Rice
Aug 21, 2013·Developmental and Comparative Immunology·Beatriz ValenzuelaBrenda Modak
Jun 15, 2007·Nature Reviews. Microbiology·Bruno Guy
Aug 22, 2017·Frontiers in Immunology·Susanta PahariJaved N Agrewala

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Marcus D SäemannGerhard J Zlabinger
Annual Review of Immunology
Jacques BanchereauK Palucka
© 2022 Meta ULC. All rights reserved