Maturation of early-phase insulin release in the neonatal lamb

Biology of the Neonate
A F PhilippsJ R Raye

Abstract

Standardized primed continuous glucose infusions were performed in 13 newborn lambs between 4 h and 2 weeks of age to assess the timing of development of glucose-induced early-phase insulin release. Lambs of less than 6 h of age behaved similar to those previously infused in utero, with no early response noted. In contrast, early-phase insulin release was present in lambs of 12 h of age and older. Although basal plasma glucose rose with increasing post-natal age, this rise was not sufficient to account for the appearance of early-phase insulin release. Factors other than the basal glucose level or the birth process itself may be operative.

Citations

Feb 24, 2011·American Journal of Physiology. Endocrinology and Metabolism·Alice S GreenSean W Limesand
Oct 14, 2008·Early Human Development·Kathryn Beardsall, David Dunger
Jul 1, 1984·Equine Veterinary Journal·A L FowdenP D Rossdale
Nov 30, 2010·Diabetes Research and Clinical Practice·R G Ahmed
May 12, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leticia E CamachoSean W Limesand
Mar 1, 2010·Expert Review of Endocrinology & Metabolism·Kathryn BeardsallDavid B Dunger

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