Abstract
Transplantation of human fetal neural cells has been used for several years as a treatment for Parkinson's disease. These therapeutic trials were based on a large number of rat allografts studies, and the species to species extrapolation appeared valid in many respects. One major difference between neurons of various species, however, is their rate of maturation; indeed, human neurons have been proven to grow much more slowly than rat neurons. This has been studied mostly, up to now, at the light microscope level. In an attempt to determine the fine structural correlates of this protracted development and to detail the schedule of morphogenesis and synaptogenesis, human fetal brain stem tissue (at 8 weeks of gestation) was transplanted into a previously lesioned brain area of immunosuppressed adult rats. Transplants, which were allowed to develop for 15 days to 3 months, were analyzed using the electron microscope. At 15 days, small cells containing a large nucleus were surrounded by wide extracellular spaces. At 1 month, grafted neurons displayed a thin rim of cytoplasm and few thin processes. At 2 months, extracellular spaces tended to diminish. Thin processes formed bundles and large processes extended from enlarged neurons....Continue Reading
References
Jan 1, 1992·Gynecologic and Obstetric Investigation·A Molin, J Brundin
Jun 1, 1992·Progress in Neurobiology·K Wictorin
Feb 2, 1990·Science·O LindvallC D Marsden
May 8, 1990·The Journal of Comparative Neurology·C SoteloF Crepel
May 8, 1990·The Journal of Comparative Neurology·R GardetteC Sotelo
Jul 15, 1990·The Journal of Comparative Neurology·I Kostovic, P Rakic
Jun 1, 1990·Neuropathology and Applied Neurobiology·M WilkinsonJ E Bell
Aug 1, 1989·Brain Research. Developmental Brain Research·I DusartM Peschanski
Jan 1, 1989·Neuroscience·F NothiasM Peschanski
Jan 1, 1989·Neuroscience·V H Perry, R D Lund
Aug 1, 1987·Neuroscience·O IsacsonA Björklund
Dec 16, 1988·Science·M B RosenbergF H Gage
Mar 1, 1988·Neuroscience·R GardetteC Sotelo
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P Bickford-WimerI Strömberg
Jun 4, 1987·Nature·C Sotelo, R M Alvarado-Mallart
Sep 10, 1981·The Journal of Comparative Neurology·N Okado
Sep 1, 1995·Neuroscience·M PeschanskiP Hantraye
Jan 1, 1995·Experimental Brain Research·H ChengL Olson
Sep 1, 1994·The Journal of Comparative Neurology·J CadusseauM Peschanski
Jun 1, 1994·Brain : a Journal of Neurology·M PeschanskiR Jeny
Sep 1, 1993·Neuroscience·E MayerS B Dunnett
Nov 1, 1993·Brain Research. Molecular Brain Research·F NothiasM F Chesselet
Jan 1, 1995·Brain Research Bulletin·C GenyM Peschanski
Jan 1, 1996·Experimental Neurology·S NaimiD Riche
Feb 1, 1996·Brain : a Journal of Neurology·G L DeferJ P Nguyen
Citations
Jun 21, 2011·PloS One·Hassan AzariBrent A Reynolds
Jul 21, 1999·Journal of Neurosurgery·M F PhilipsT K McIntosh
Jul 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Anne-Catherine Bachoud-LéviMarc Peschanski
Jul 12, 2002·Journal of Neuroscience Research·Delphine BuchetJacques Mallet
Apr 21, 2009·Biomaterials·Yi XiongJun Li
Feb 15, 2001·Experimental Neurology·E D ClarksonC R Freed
Sep 21, 2010·Experimental Neurology·T B FreemanS B Dunnett
Dec 16, 1998·Pediatric Research·G BoehmJ P Colombo
Feb 27, 2014·Asian Cardiovascular & Thoracic Annals·Mohammad Ali Sadr-AmeliMona Heidarali
May 16, 2000·Cell Transplantation·C Watts, S B Dunnett
Nov 22, 2013·Neuroreport·Jenny NelanderMalin Parmar
May 16, 2000·Cell Transplantation·R J Armstrong, C N Svendsen
Apr 28, 2000·Cell Transplantation·R J ArmstrongA E Rosser