Maturation of heart valve cell populations during postnatal remodeling

Development
Alexia HulinKatherine E Yutzey

Abstract

Heart valve cells mediate extracellular matrix (ECM) remodeling during postnatal valve leaflet stratification, but phenotypic and transcriptional diversity of valve cells in development is largely unknown. Single cell analysis of mouse heart valve cells was used to evaluate cell heterogeneity during postnatal ECM remodeling and leaflet morphogenesis. The transcriptomic analysis of single cells from postnatal day (P)7 and P30 murine aortic (AoV) and mitral (MV) heart valves uncovered distinct subsets of melanocytes, immune and endothelial cells present at P7 and P30. By contrast, interstitial cell populations are different from P7 to P30. P7 valve leaflets exhibit two distinct collagen- and glycosaminoglycan-expressing interstitial cell clusters, and prevalent ECM gene expression. At P30, four interstitial cell clusters are apparent with leaflet specificity and differential expression of complement factors, ECM proteins and osteogenic genes. This initial transcriptomic analysis of postnatal heart valves at single cell resolution demonstrates that subpopulations of endothelial and immune cells are relatively constant throughout postnatal development, but interstitial cell subpopulations undergo changes in gene expression and cell...Continue Reading

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Citations

Feb 20, 2020·Circulation Research·Felix GunawanAnabela Bensimon-Brito
May 23, 2020·Journal of Cardiovascular Development and Disease·Neha AhujaDeborah Garrity
Aug 15, 2020·Development·Moritz Jakab, Hellmut G Augustin
Jun 30, 2019·Development·Allon M Klein, Barbara Treutlein
Mar 15, 2020·Cardiovascular Research·Andrew J KimKatherine E Yutzey
Jul 6, 2020·Development·Anna O'Donnell, Katherine E Yutzey
Sep 30, 2020·Journal of Cardiovascular Development and Disease·Deborah J HendersonBill Chaudhry
Nov 12, 2020·International Journal of Molecular Sciences·Shintaro Yamada, Seitaro Nomura
Dec 18, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Farwah IqbalElena Aikawa
Jan 30, 2021·Circulation Research·Sergiy KyryachenkoNabila Bouatia-Naji
Mar 7, 2021·International Journal of Molecular Sciences·Elvira ForteNadia A Rosenthal
Aug 29, 2020·International Journal of Cardiology·Emilie FaureStéphane Zaffran
May 1, 2021·Journal of Cardiovascular Development and Disease·Sonia StefanovicStéphane Zaffran
Apr 30, 2021·Circulation Research·Mark C BlaserElena Aikawa
Jun 21, 2021·Current Opinion in Cell Biology·Felix GunawanDidier Y R Stainier
Oct 15, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Emily M NordquistJoy Lincoln

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