Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor?

Cerebral Cortex
Y PatelIMAGEN consortium

Abstract

Previous in vivo studies revealed robust age-related variations in structural properties of the human cerebral cortex during adolescence. Neurobiology underlying these maturational phenomena is largely unknown. Here we employ a virtual-histology approach to gain insights into processes associated with inter-regional variations in cortical microstructure and its maturation, as indexed by magnetization transfer ratio (MTR). Inter-regional variations in MTR correlate with inter-regional variations in expression of genes specific to pyramidal cells (CA1) and ependymal cells; enrichment analyses indicate involvement of these genes in dendritic growth. On the other hand, inter-regional variations in the change of MTR during adolescence correlate with inter-regional profiles of oligodendrocyte-specific gene expression. Complemented by a quantitative hypothetical model of the contribution of surfaces associated with dendritic arbor (1631 m2) and myelin (48 m2), these findings suggest that MTR signals are driven mainly by macromolecules associated with dendritic arbor while maturational changes in the MTR signal are associated with myelination.

References

Jul 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M J Hawken, A J Parker
Jun 1, 1987·The Journal of Comparative Neurology·G EinsteinP Sterling
Mar 1, 1994·Radiographics : a Review Publication of the Radiological Society of North America, Inc·R I GrossmanM D Schnall
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R M HenkelmanM J Bronskill
Mar 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigR Ugolini
Oct 31, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I M VavasourD W Paty
Dec 5, 1998·Magnetic Resonance Imaging·M D DoesR E Snyder
Apr 26, 2001·NMR in Biomedicine·R M HenkelmanS J Graham
Jan 9, 2003·Current Opinion in Cell Biology·Gregory J Pazour, George B Witman
Jun 20, 2003·Journal of Neurocytology·Ruth Benavides-PiccioneRafael Yuste
Sep 7, 2004·Annals of Neurology·Klaus SchmiererDavid H Miller
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·John Zeqi Luo, Luguang Luo
Feb 20, 2009·The Journal of Comparative Neurology·Frederico A C AzevedoSuzana Herculano-Houzel
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Schanila NawazMikael Simons
Jul 4, 2009·NeuroImage·Douglas N Greve, Bruce Fischl
Jan 26, 2010·Neurobiology of Disease·Jeong Ho Lee, Joseph G Gleeson
Aug 12, 2010·PLoS Computational Biology·Hermann CuntzMichael Häusser
Nov 26, 2010·Molecular Psychiatry·G SchumannUNKNOWN IMAGEN consortium
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zdravko PetanjekIvica Kostovic
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine Lebel, Christian Beaulieu
Feb 14, 2012·Current Biology : CB·Hiroaki IshikawaWallace F Marshall
Sep 22, 2012·Nature·Michael J HawrylyczAllan R Jones
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Daniel J MillerChet C Sherwood
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah M GuadianaMatthew R Sarkisian
Mar 27, 2013·Cerebral Cortex·Giorgio M InnocentiRoberto Caminiti
May 15, 2013·NeuroImage·Matthew F GlasserUNKNOWN WU-Minn HCP Consortium
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Serena BianchiChet C Sherwood
Jan 3, 2014·Physiological Reviews·Carlo Sala, Menahem Segal
Oct 7, 2015·Frontiers in Neuroscience·Leon French, Tomáš Paus

❮ Previous
Next ❯

Citations

Jul 30, 2020·Human Brain Mapping·Christopher R K ChingUNKNOWN ENIGMA Bipolar Disorder Working Group
Mar 11, 2020·Human Brain Mapping·Odile A van den HeuvelUNKNOWN ENIGMA-OCD working group
Jun 26, 2020·JAMA Psychiatry·Nadine ParkerUNKNOWN Saguenay Youth Study and the IMAGEN Consortium
Dec 20, 2020·Journal of Neuroendocrinology·Jean ShinZdenka Pausova
Aug 29, 2020·JAMA Psychiatry·UNKNOWN Writing Committee for the Attention-Deficit/Hyperactivity DisorderTomáš Paus
Jan 30, 2021·AJNR. American Journal of Neuroradiology·I ColonnaS Ropele
Feb 23, 2021·Human Brain Mapping·Ida E SønderbyUNKNOWN ENIGMA 22q11.2 Deletion Syndrome Working Group
Jan 12, 2021·Cerebral Cortex·Zhijie LiaoTomas Paus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.