Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty: II. Reduced potency of an inhibitory autofeedback

Endocrinology
J P BourguignonP Franchimont

Abstract

At the time of onset of puberty in the male rat, between 15 and 25 days of age, we have reported that pulsatile GnRH secretion by hypothalamic explants showed an increased frequency as indicated by the reduction of the mean interpulse interval from 66 to 40 min (P less than 0.05). This study aimed to evaluate whether these changes in GnRH secretion involved a self-regulatory mechanism. A 7.5-min exposure of explants obtained at 50 days to 0.1 microM superagonist D-TRP6-PRO9-N-Et-GnRH (GnRH-A) resulted in a delay of the next GnRH secretory pulse so that the mean interpulse interval increased from 35 to 67 min (P less than 0.001). In addition, after a 7.5-min exposure to GnRH-A, there was a 15-min period with absent or reduced release of GnRH in response to 50 microM veratridine, a depolarizing agent. A similar refractory period of 15 min was observed using explants obtained at 25 and 50 days whereas, at 15 days, the period of refractoriness lasted for 52.5 min. The inhibitory effect of GnRH-A on the subsequent response to veratridine occurred at similar concentrations of GnRH-A at the three studied ages and the inhibition was prevented using an antagonist of GnRH together with GnRH-A. The involvement of GnRH itself in an autofee...Continue Reading

Citations

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L Z KrsmanovićK J Catt
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L Z KrsmanovićK J Catt
Jun 1, 1994·Journal of Neuroendocrinology·C Smyth, M Wilkinson
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·J P BourguignonP Franchimont
Jan 1, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·A BüyükgebizB Büyükgebiz
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·L ZhengS S Stojilkovic
Jul 8, 1993·The Journal of Comparative Neurology·K L Buchanan, S M Yellon
Mar 3, 2004·Annals of the New York Academy of Sciences·Valérie MatagneJean-Pierre Bourguignon
Dec 10, 2014·The Journal of Clinical Endocrinology and Metabolism·N D ShawJ E Hall
Jun 10, 2010·Journal of Endocrinological Investigation·B PredieriUNKNOWN Italian Society of Pediatric Endocrinology and Diabetology-Study Group of Puberty
Jul 14, 2005·Proceedings. Biological Sciences·Matthew H McIntyreBradford Towne

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