Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity.

Proceedings of the National Academy of Sciences of the United States of America
Shizue OhsawaMasayuki Miura

Abstract

Although the apoptotic role of caspases has been largely understood, accumulating evidence in Drosophila suggests that caspases also control other processes than apoptotic cell death. However, how caspases contribute to the development of the mammalian nervous system remains obscure. Here, we provide unique evidence that Apaf-1/caspase-9-mediated caspase signaling regulates the development of olfactory sensory neurons (OSNs), which includes axonal projection, synapse formation, and maturation of these neurons. This caspase signaling leads to a cleavage of Semaphorin 7A, a membrane-anchored semaphorin that is required for the proper axonal projection. Mutant mice deficient for apaf-1 or caspase-9 exhibit misrouted axons, impaired synaptic formation, and defects in the maturation of OSNs without affecting the number of these cells. Our findings suggest that Apaf-1/caspase-9-mediated nonapoptotic caspase signaling is required for the proper neural network formation during olfactory development.

References

Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Nov 15, 1996·Cell·P MombaertsR Axel
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·C ForcetP Mehlen
Feb 14, 2002·Science's STKE : Signal Transduction Knowledge Environment·Zhigang HeHong-Jun Song
Aug 3, 2002·Journal of Neuropathology and Experimental Neurology·Jeffrey R LeonardKevin A Roth
Feb 21, 2003·Current Opinion in Neurobiology·R Jeroen Pasterkamp, Alex L Kolodkin
Jul 25, 2003·Nature·R Jeroen PasterkampAlex L Kolodkin
May 25, 2004·The Journal of Comparative Neurology·Catherine M Cowan, A Jane Roskams
Jun 5, 2004·Science·Dong-Jing ZouStuart Firestein
Jan 7, 2005·Journal of Neuroscience Research·Shizue OhsawaMasayuki Miura
Jan 29, 2005·Development·Sei-ichi YoshiharaYoshihiro Yoshihara
May 20, 2005·Nature·Vanessa DepaepePierre Vanderhaeghen
Mar 31, 2006·The Journal of Comparative Neurology·Albert BlanchartLaura López-Mascaraque
Nov 30, 2007·Developmental Neurobiology·Takuro MaruyamaNobuhiko Yamamoto
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ronald W OppenheimChanglian Zhu
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shizue OhsawaMasayuki Miura

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Citations

Jul 4, 2012·Molecular Neurobiology·Susana SoláCecília M P Rodrigues
Jun 12, 2013·Nature Communications·Julio PozuetaMichael Shelanski
May 19, 2012·Nature Reviews. Neuroscience·Bradley T Hyman, Junying Yuan
Feb 23, 2011·Development, Growth & Differentiation·Masayuki Miura
May 16, 2012·Molecular Brain·Zheng Li, Morgan Sheng
May 26, 2012·PloS One·Giuseppa PistrittoMaria Luisa Barbaccia
Jan 15, 2014·PloS One·Mónica SanchoEnrique Pérez-Payá
Aug 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kai ChengLeonardo Belluscio
Dec 8, 2010·Neurochemical Research·Masayuki Miura
Jan 5, 2014·The Journal of Cell Biology·Douglas S Campbell, Hitoshi Okamoto
Jan 22, 2013·Seminars in Cell & Developmental Biology·Bart C JongbloetsR Jeroen Pasterkamp
Dec 12, 2012·Seminars in Cell & Developmental Biology·Paolo Giacobini, Vincent Prevot
May 11, 2011·Journal of Neuroendocrinology·M-C LacroixF Renaud
Aug 15, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sarah A Dick, Lynn A Megeney
Mar 19, 2014·Developmental Cell·Jin-Yuan WangZhen-Ge Luo
May 16, 2015·Cellular and Molecular Life Sciences : CMLS·Daniela De ZioElisabetta Ferraro
Jul 17, 2012·Trends in Neurosciences·Marcello D'AmelioFrancesco Cecconi
Dec 20, 2014·Cell Death and Differentiation·S ShaliniS Kumar
Jun 9, 2016·Archives of Oral Biology·Tathyane H N TeshimaSilvia V Lourenço
May 24, 2018·PloS One·Olivia SpeadFabienne E Poulain
Feb 24, 2016·Development·Cláudio Gouveia RoqueChristine E Holt
Jul 14, 2018·The Journal of Comparative Neurology·Seiya Yamada, Shin-Ichi Sakakibara
Jan 25, 2018·Cell Death and Differentiation·Lorenzo GalluzziGuido Kroemer
Jul 21, 2011·Cell Biochemistry and Function·Engin UlukayaYusuf Yilmaz
Mar 25, 2017·Cell Death and Differentiation·Ryan A V Bell, Lynn A Megeney
Aug 10, 2012·Physiology·Claudia Lodovichi, Leonardo Belluscio
Nov 22, 2019·Frontiers in Cellular Neuroscience·Ana María Espinosa-OlivaMiguel Angel Burguillos
Jun 25, 2020·Nature Communications·Maria I AvrutskyCarol M Troy
Apr 4, 2021·International Journal of Molecular Sciences·Julie BasGermain Gillet
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Trang Thi Minh NguyenNikolay Popgeorgiev
Jul 27, 2021·Frontiers in Pharmacology·Maria I Avrutsky, Carol M Troy
Oct 8, 2021·BMC Molecular and Cell Biology·Gabriel KrasovecJean-Philippe Chambon

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