Maturation of TonEBP expression in developing rat kidney

American Journal of Physiology. Renal Physiology
Ki-Hwan HanH Moo Kwon

Abstract

Tonicity-responsive enhancer binding protein (TonEBP) is a transcriptional activator of the Rel family. In the renal medulla, TonEBP stimulates genes encoding proteins involved in cellular accumulation of organic osmolytes, the vasopressin-regulated urea transporters (UT-A), and heat shock protein 70. To understand the role of TonEBP in the development of urinary concentrating ability, TonEBP expression during rat kidney development was investigated. In embryonic kidneys, TonEBP immunoreactivity was detected 16 days postcoitus in the cytoplasm of the endothelial cells surrounding the medullary collecting ducts (MCD). By 20 days, TonEBP was detected in most tubular profiles in the medulla, including the loop of Henle and MCD, and interstitial cells. The intensity of TonEBP immunoreactivity was much higher in the vasa recta than the tubules. In addition, immunoreactivity was localized predominantly to the cytoplasm. On postnatal day 1, two major changes were observed. TonEBP immunoreactivity shifted to the nucleus, and the intensity of TonEBP immunoreactivity of the tubules increased dramatically. These changes were associated with an increase in TonEBP and sodium-myo-inositol cotransporter mRNA abundance. Thereafter, TonEBP expr...Continue Reading

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Citations

Apr 16, 2010·American Journal of Physiology. Renal Physiology·Ki-Hwan HanI David Weiner
Dec 28, 2012·Journal of Lipid Research·Cecilia I CasaliMaría C Fernández Tome
Aug 16, 2008·The Journal of Biological Chemistry·Udo HaslerEric Féraille
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Jul 4, 2013·Journal of Veterinary Science·Su-Youn LeeKi-Hwan Han
Dec 2, 2004·American Journal of Physiology. Renal Physiology·Ki-Hwan HanJin Kim
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Jun 1, 2007·Electrolyte & Blood Pressure : E & BP·Ju-Young JungJim Kim
Feb 2, 2006·American Journal of Physiology. Renal Physiology·James Y YangStephen S M Chung
Apr 6, 2007·American Journal of Physiology. Renal Physiology·Un Sil JeonH Moo Kwon
Aug 24, 2006·American Journal of Physiology. Renal Physiology·Hyun-Wook LeeJin Kim
Sep 8, 2016·Oncology Letters·Christoph KüperWolfgang Neuhofer
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Ki-Hwan HanOh-Joo Kwon
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Udo HaslerEric Féraille

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