Maturation-resistant dendritic cells ameliorate experimental autoimmune uveoretinitis.

Immune Network
Keunhee OhDong-Sup Lee

Abstract

Endogenous uveitis is a chronic inflammatory eye disease of human, which frequently leads to blindness. Experimental autoimmune uveoretinitis (EAU) is an animal disease model of human endogenous uveitis and can be induced in susceptible animals by immunization with retinal antigens. EAU resembles the key immunological characteristics of human disease in that both are CD4(+) T-cell mediated diseases. Dendritic cells (DCs) are specialized antigen-presenting cells that are uniquely capable of activating naïve T cells. Regulation of immune responses through modulation of DCs has thus been tried extensively. Recently our group reported that donor strain-derived immature DC pretreatment successfully controlled the adverse immune response during allogeneic transplantation. EAU was induced by immunization with human interphotoreceptor retinoid-binding protein (IRBP) peptide(1-20). Dendritic cells were differentiated from bone marrow in the presence of recombinant GM-CSF. In this study, we used paraformaldehyde-fixed bone marrow-derived DCs to maintain them in an immature state. Pretreatment with fixed immature DCs, but not fixed mature DCs, ameliorated the disease progression of EAU by inhibiting uveitogenic CD4(+) T cell activation an...Continue Reading

References

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Citations

Apr 2, 2013·Progress in Retinal and Eye Research·John V ForresterMatthew E Wikstrom
Mar 10, 2015·Survey of Ophthalmology·Ping ChenRobert B Nussenblatt
Oct 31, 2012·Progress in Retinal and Eye Research·Manabu MochizukiKoju Kamoi
Jul 29, 2020·Frontiers in Immunology·Atsunobu TakedaKoh-Hei Sonoda
May 16, 2018·Experimental Eye Research·M O'RourkeM Canavan

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Methods Mentioned

BETA
fluorescence microscopy

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