PMID: 9662561Jul 15, 1998Paper

Maturational changes in rabbit renal brush border membrane vesicle osmotic water permeability

The Journal of Membrane Biology
R QuigleyM Baum

Abstract

We have recently shown that the osmotic water permeability (Pf) of proximal tubules from neonatal rabbits is higher than that of adults (AJP 271:F871-F876, 1996). The developmental change in Pf could be due to differences in one or more of the components in the path for transepithelial water transport. The present study examined developmental changes in water transport characteristics of the proximal tubule apical membrane by determining Pf and aquaporin 1 (AQP1) expression in neonatal (10-14 days old) and adult rabbit renal brush border membrane vesicles (BBMV). AQP1 abundance in the adult BBMV was higher than the neonatal BBMV. At 25 degrees C the Pf of neonatal BBMV was found to be significantly lower than the adult BBMV at osmotic gradients from 50 to 250 mOsm/kg water. The activation energy for osmotic water movement was higher in the neonatal BBMV than the adult BBMV (9.19 +/- 0.37 vs. 5.09 +/- 0.57 kcal . deg-1 . mol-1, P < 0.005). Osmotic water movement in neonatal BBMV was inhibited 17.9 +/- 1.3% by 1 mm HgCl2 compared to 34.3 +/- 3.8% in the adult BBMV (P < 0.005). These data are consistent with a significantly greater fraction of water traversing the apical membrane lipid bilayer in proximal tubules of neonates than ...Continue Reading

Citations

Jun 18, 2004·Seminars in Perinatology·Michel Baum, Raymond Quigley
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaap MulderRaymond Quigley
Aug 16, 2003·Current Opinion in Nephrology and Hypertension·Michel BaumLisa Satlin
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R QuigleyM Baum
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Raymond Quigley, Michel Baum

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