PMID: 7524271Apr 1, 1994Paper

Maturational changes in sympathetic and sensory innervation of the rat uterus: effects of neonatal capsaicin treatment

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
M M BrauerG Burnstock

Abstract

The plasticity of the sympathetic and sensory innervation of the rat uterus was examined, before and after puberty, in controls and in animals where primary sensory nerves had been destroyed by neonatal capsaicin treatment. Immunohistochemical and histochemical methods were used in association with nerve density measurements and biochemical assays. The main findings were as follows: (1) Puberty was associated with a marked increase in the weight of the uterine horn, uterine cervix and parametrial tissue. This was unaffected by capsaicin treatment. (2) The sympathetic innervation of the uterine horn and parametrial tissue was reduced following puberty as revealed by a decrease in the density of noradrenaline-containing nerves and a marked decrease in the tissue concentration of noradrenaline. Sympathetic nerves supplying the uterine cervix and the blood vessels of the uterus appeared to be unaffected by puberty. (3) In contrast, the sensory supply of the uterus by substance P and calcitonin gene-related peptide-containing nerves increased in parallel with uterine growth during puberty resulting in no change in nerve density and only a slight reduction in peptide concentration. (4) Neonatal capsaicin treatment caused a long-lasti...Continue Reading

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Citations

Oct 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M M BrauerG Burnstock
Aug 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P MilnerG Burnstock
Dec 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M M BrauerG Burnstock
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·M M MauerT J Bartness
Mar 3, 1998·Progress in Neurobiology·T Cowen, I Gavazzi
Jun 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A M CorbachoT Pérez
Jul 17, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M M Brauer, G Burnstocks
Apr 29, 1998·British Journal of Pharmacology·C PinnaG Burnstock
Aug 14, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antonio MalvasiAndrea Tinelli
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff

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