Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease

Experimental Neurology
G ToccoG Pasinetti

Abstract

We explored the constitutive expression, maturational regulation, and relation to kainic-acid-induced apoptosis of cyclooxygenase (COX)-2 mRNA in rat brain. In adult rats, COX-2 mRNA was expressed primarily in limbic structures. Constitutive COX-2 mRNA expression increased markedly between Postnatal Day 7 (P7) and P14, reaching adult levels by P21. Despite intense KA-induced seizures, no COX-2 mRNA induction was found before P14 in any brain region examined. During response to KA-induced seizures in adult brain, COX-2 mRNA induction paralleled temporally and overlapped anatomically the appearance of cellular morphological features of apoptosis in subsets of cells of the pyramidal neuron layer of the hippocampal formation, amygdaloid complex, and pyriform cortex. While COX-2 mRNA showed KA-induced elevation in the granule cell layer of the dentate gyrus, no detectable morphological features of apoptosis were found in this region. Finally, monotypic culture of rat corticohippocampal neurons confirmed the neuronal expression of COX-2 in vitro and revealed that COX-2 is induced during response to glutamate treatment, leading to neuron death. These studies may provide novel insights into the role of COX-2 and mechanisms of action of...Continue Reading

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Citations

Sep 17, 1999·The American Journal of Pathology·K A KelleyG M Pasinetti
Apr 3, 1999·British Journal of Pharmacology·R BrambillaM P Abbracchio
Dec 1, 1999·British Journal of Pharmacology·J A Mitchell, T D Warner
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Jan 5, 2001·Expert Opinion on Investigational Drugs·M K O'Banion
Jan 24, 2014·BioMed Research International·Hsi-Lung Hsieh, Chuen-Mao Yang
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Jul 21, 1999·Journal of Neuroscience Research·L HoG M Pasinetti
Jun 28, 2006·Annals of Neurology·Merit E CudkowiczDaniel B Drachman

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